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BioEngenuity Keynotes & Poster Session

Join The Institute of Biomedical Engineering for the fourth BioEngenuity Keynote followed by a networking lunch and interactive poster session.
When Nov 02, 2017
from 11:00 AM to 02:00 PM
Where Richard Doll Lecture Theatre
Contact Name
Contact Phone 01865 617706
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Keynote Speakers


Tim Denison, VP of Research and Core Technology for Medtronic

Creating Neural “Co-processors” to Explore Treatments for Neurological Disorders.

The impact of neurological disorders is felt at many levels; from personal to the socioeconomic. While neuromodulation has made in-roads in treating some conditions, overall success is limited by questions regarding the neuroscience-based mechanisms of action for optimizing treatment.

To address this knowledge gap, public-private teams are collaborating on building and deploying investigational research tools for studying the human nervous system. By allowing the prototyping of therapeutic concepts from a dynamic systems perspective, researchers are able to explore the capability of bioelectronic systems that act more as a neurological “co-processor”, or prosthesis, to address disease symptoms, as opposed to the fixed-pattern stimulators used today.

This talk will provide a technical perspective on the state-of-the-art for this neurotechnology direction, some promising areas for potential clinical translation, and the remaining challenges.

Professor Wladyslaw Gedroyc, Director & Consultant Radiologist, Imperial College Healthcare

MR guided transcranial brain focused ultrasound

This talk will describe the current work being undertaken to treat essential tremor and other motion disorders utilising externally applied non-invasive focused ultrasound which is applied through the intact cranium.

Currently the majority of the work in this field is being carried out in the treatment of essential tremor which is a very common often severely debilitating motion disorder. Areas of ablation are created in the nucleus ventralis intermedius and adjacent structures to interrupt aberrant electrical pathways which are driving patients tremor. The transcranial focused ultrasound system utilising thermal mapping and highly precise targeting can produce small discrete lesions in this precise area which when correlated with clinical feedback provides an excellent way of relieving patients tremor symptomatology.

The success of this therapy indicates that other areas of ablation and treatment can be carried out within the brain utilising similar approaches and extensive work is underway to develop treatments in Parkinson’s disease and other motion disorders. Similarly the ability to carry out non-invasive destructive ablations within the brain may allow the development of multiple other therapeutic manoeuvres within the brain such as drug release and increasing chemotherapy delivery to tumours which may change our approach to central brain therapies in the coming decade. Effectiveness of this therapy in motion disorders to date has been remarkable and is completely non-invasive and can often be done entirely as an outpatient.

  

Biographies

 Tim Denison, VP of Research and Core Technology for Medtronic

Tim is the Vice President of Research and Core Technology, Implantable Systems, for the Restorative Therapies group of Medtronic PLC.  He was named a technical fellow in 2010, received Medtronic's highest technical and scientific award, membership in the Bakken Society in 2012, and was honored with the Wallin Leadership Award in 2014. Tim was named to the College of Fellows for the American Institute of Medical and Biological Engineering in 2015.

Tim Denison received his M.S. and Ph.D. in Electrical Engineering from the Massachusetts Institute of Technology, and his A.B. in Physics from the University of Chicago. He is currently completing an MBA at the University of Chicago.

Tim’s extracurricular pursuits include serving as an associate editor for the IEEE Transactions on Biomedical Circuits and Systems/Biomedical Engineering, and on the editorial board of the Journal of Neural Engineering.

 

Professor Wladyslaw Gedroyc, Director & Consultant Radiologist, Imperial College Healthcare

Prof Gedroyc is a consultant radiologist at Saint Mary's hospital and Imperial healthcare trust. He has been involved in research in image guidance of therapy using MR for 18 years. Currently involved in extensive work with focused ultrasound applications to a variety of areas. More recently involved with developing and applying brain focused ultrasound in a  variety of emerging areas.

Prof Gedroyc is joint chief editor of the Journal of therapeutic ultrasound and joint president of the European focused ultrasound symposium.

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