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Biomedical Engineering Seminar - 10 March 2015

Speaker: Dr Robert Eckersley, King's College London. Title: Super Resolution Ultrasound Imaging
When Mar 10, 2015
from 12:45 PM to 01:45 PM
Where IBME F1 Seminar Room (20.61), Old Road Campus Research Building, Headington, OXFORD
Contact Name
Contact Phone 01865 617747/617737
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BME 10.3.15

Abstract in full

Angiogenesis is an important component of many disease states, including the growth and metastasis of tumours. Many micro-vascular diseases, such as those associated with diabetes and coronary heart disease exhibit architectural changes in micro-vascular structure, as well as variations in vascular flow. Current clinical imaging modalities such as MRI, PET, CT and Ultrasound cannot easily resolve the microvasculature and are instead mainly used to determine functional indicators like blood flow velocity. Although optical light microscopy is able to resolve microscopic structures on the scale of microvasculature, the restricted imaging depth of this approach is a major limitation. Thus, there is a clinical need for the development of new imaging techniques that can fill this resolution gap. 

Using an unmodified clinical Ultrasound system in a standard contrast enhanced mode we have demonstrated super-resolution imaging through the use of a low concentration of a microbubble contrast agent. The technique works by identifying individual bubble signals and the precise localisation of the origin of these signals. More recently we have published the first in vivo demonstration of  this Ultrasound super-resolution technique where structures under 20 μm are resolved using an US wavelength of 230 μm. Currently we are extending our work to facilitate three dimensional localisation preliminary work on this aspect will also be presented.  

References 

Viessmann, O M, Eckersley, R J, Christensen-Jeffries, K, Tang, M X, & Dunsby, C. (2013). Acoustic super-resolution with ultrasound and microbubbles. Physics in Medicine and Biology, 58(18), 6447.

Christensen-Jeffries, Kirsten, Browning, Richard J., Tang, Meng-Xing, Dunsby, Christopher, & Eckersley, Robert J. (2015). In vivo acoustic super-resolution and super-resolved velocity mapping using microbubbles. IEEE Transactions On Medical Imaging, 34(2), 433-440. doi: 10.1109/tmi.2014.2359650

Biography in full

Dr Robert Eckersley is a Senior Lecturer in the Biomedical Engineering Department of the Division of Imaging Sciences at King’s College London (KCL). His background is in Physics applied to medical US imaging. He has been the recipient of a MRC non-clinical research training fellowship and through this and subsequent funding from the EPSRC (GR/S71224/01, EP/F066740/1, & EP/G038163/1) he has specialised in developing the use of microbubbles for medical US imaging. His research continues to cover a wide range of disciplines from clinical applications to fundamental studies. He is also a co-investigator on a recent award from the Wellcome Trust and EPSRC with the aim of developing a multi-probe computer-guided ultrasound imaging system for prenatal screening and comprehensive diagnosis of foetal abnormalities.