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Biomedical Engineering Seminar - 2 June 2015

Speaker: Professor Richard Guy, Professor of Pharmaceutical Sciences, Bath University. Title: Imaging drug delivery to skin and nail with micro(spectro)scopic techniques.
When Jun 02, 2015
from 12:45 PM to 01:45 PM
Where Ludwig/Jenner Seminar Room, Rm 678.00.59A, Old Road Campus Research Building, Headington, Oxford
Contact Name
Contact Phone +44(0)1865 617737/617747
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Coherent Raman scattering microscopy allows high-resolution, non-destructive, label-free, three-dimensional imaging of the skin and nail, with chemical contrast obtained based on Raman scattering. The penetration pathway(s) of the drug and excipients from a topical formulation can be visualized independently, and its “metamorphosis” post-application at the surface of the skin or nail can be imaged in real-time. Furthermore, Coherent Raman scattering microscopy is an excellent tool, either alone or in conjunction with more conventional confocal fluorescence microscopy, with which to image lipophilic micro- and/or nanoparticle-based formulations or, when combined with atomic force microscopy and micro-spectroscopic mapping, to characterise the behaviour of polymer-based film-forming systems for sustained drug delivery to the skin.


Richard Guy received an M.A. in Chemistry from Oxford University, and his Ph.D. in Pharmaceutical Chemistry from the University of London. He has held academic posts at the University of California, San Francisco and the University of Geneva. In 2004, he joined the University of Bath as Professor of Pharmaceutical Sciences in the Department of Pharmacy & Pharmacology. Dr. Guy is an elected fellow of the Royal Society of Chemistry, the Controlled Release Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science.  Dr. Guy was named a Fellow of the UCL School of Pharmacy, in recognition of “his distinguished contribution to the pharmaceutical sciences”, and was awarded the Controlled Release Society’s Founders Award in 2013.  Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability.  He has published 350+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents.

Imaging Drug Delivery to Skin with Stimulated Raman Scattering Microscopy.  B.G. Saar, L.R. Contreras-Rojas, X.S. Xie and R.H. Guy.  Molecular Pharmaceutics, 8: 969-975 (2011).

Objective Assessment of Nanoparticle Disposition in Mammalian Skin after Topical Exposure.   C. Campbell, L.R. Contreras-Rojas, M.B. Delgado-Charro and R.H. Guy.  J. Control. Release, 162: 201-207 (2012).

Evaluation of Drug Delivery to Intact and Porated Skin by Coherent Raman Scattering and Fluorescence Microscopies. N.A. Belsey, N.L. Garrett, L.R. Contreras-Rojas, A.J. Pickup-Gerlaugh, G.J. Price, J. Moger and R.H. Guy.  J. Control. Release 174: 37-42 (2014).

Characterisation of Topical Film-forming Systems Using Atomic Force Microscopy and Raman Micro-spectroscopy.  H. Garvie-Cook, K. Frederiksen, R.H. Guy, K. Petersson and S. Gordeev.  Mol. Pharmaceut.  12: 751-755 (2015).

Molecular Diffusion in the Human Nail Measured by Stimulated Raman Scattering Microscopy.  W.S. Chiu, N.A. Belsey, N.L. Garrett, J. Moger, M.B. Delgado-Charro and R.H. Guy.  Proc. Natl. Acad. Sci., USA, in press (2015).