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Cardiovascular imaging (functional assessment)

Functional cardiology - assessing heart function

Fusion 3DechoProfessor Noble's research group has been working on various aspects of echocardiographic image analysis for a number of years. Early work focussed on spatio-temporal analysis, including Kalman-filter based tracking, and local phase-based segmentation and tracking. Recent contributions include pioneering the use of fusion echocardiography to improve the quality of echocardiography for both visual and automated interpretation. On-going projects are looking at different aspects of 2D and 3D echocardiographic (ultrasound) image analysis, and combining echocardiography and MR imagery.

For instance we are looking at ways to analyse what is called stress echocardiography which is where you image a heart at rest and then again when it is stressed (made to do work). Cardiologists use these images to assess the health of the heart but by-eye assessment is very subjective. We are looking at ways to model the change in the heart from rest to stress and also at what quantitative measures can be extracted to characterize a heart that undergoes this change in function.

We are also looking at fusing 3D echo data from different views and how this can be used to give more complete visualizations of large left ventricles and improve quantification (see Figure right).  Finally we have developed the first published approach to align 3D echo and MR data which opens up the way to use both modalities in cardiac diagnosis and treatment monitoring.

  • Functional Cardiology Team: Alison Noble, Richard Stebbing, John Mcmanigle, Kiryl Cheyky, Michael Tee, João Domingos
  • Collaborators: Paul Leeson (OCCF), Harald Becher (U. Alberta, Canada), Cezary Szmigielski, David Bluemke (NIH, USA)
  • Funding: EPSRC, NIH OxCam

Representative Publications (see also laboratory full publication list):

D Augustine, C Szmigielski, E Lima, S Neubauer, S Petersen, H Becher, A Noble, P Leeson,
3D fusion echocardiography improves 3D left ventricular assessment: comparison with 2D contrast echocardiography.
European Society of Cardiology (ESC), accepted for oral presentation, 2013.

JE McManigle, RV Stebbing, JA Noble
Modified Hough transform for left ventricle myocardium segmentation in 3-d echocardiogram images.
Proceedings of the International Symposium on Biomedical Imaging (ISBI) - IEEE, 2 - 5 May 2012, Barcelona, pp. 290-293.

RV Stebbing, JE McManigle, JA Noble.
Interpreting edge information for improved endocardium delineation in echocardiograms.
Proceedings of the International Symposium on Biomedical Imaging (ISBI) - IEEE, 2 - 5 May 2012, Barcelona, Spain, pp. 238-241.

W Zhang, JM Brady, H Becher, JA Noble.
Spatio-temporal (2D+T) non-rigid registration of real-time 3D echocardiography and cardiovascular MR image sequences.
Physics in Medicine and Biology 56(5), 2011.

K Rajpoot, V Grau, JA Noble, H Becher, C Szmigielski.
The evaluation of single-view and multi-view fusion 3D echocardiography using image-driven segmentation and tracking.
Medical Image Analysis, 15(4):514-528, August 2011.

C Szmigielski, K Rajpoot, V Grau, SG Myerson, C Holloway, JA Noble, R Kerber, H Becher
Real-time 3D Fusion Echocardiography

Journal of the American College of Cardiology: Cardiovascular imaging, 3:682:690, 2010.

J Bermejo, J. Timperley, R. Odremann, M, Mulet, J.A. Noble, A.P. Banning, R Yotti, E Perez-David, J Declerck, H. Becher, M.A. Garcia-Fernandez
Objective quantification of global and regional left ventricular systolic function by endocardial tracking of contrast echocardiographic sequences
International Journal of Cardiology, 2008.

G. Jacob, J. A. Noble, C. Behrenbruch, A.D. Kelion and A.P. Banning
A shape-space based approach to tracking myocardial thickening and quantifying regional left ventricular function
IEEE Trans. Medical Imaging, 21(3), p. 226-238, 2002.

M. Mulet-Parada and J.A. Noble
2D+T boundary detection in echocardiography
Medical Image Analysis, 4(1), p.21-30, 2000.

G. Jacob, J.A. Noble, M. Mulet-Parada and A. Blake
Evaluating a robust contour tracker on echocardiographic sequences
Medical Image Analysis, 3(1), p.63-76, 1999