John McManigle is a DPhil student working on 3d cardiac image segmentation and registration. His research aims to combine cardiac MRI and ultrasound images to provide better image guidance in interventional cardiology and electrophysiology.
John grew up in Silver Spring, Maryland, where he graduated from the Montgomery Blair High School Magnet Program. He earned a BS in Physics with Honors from The Pennsylvania State University, and is now pursuing a combined MD/DPhil programme. John will earn his MD from Duke University and his DPhil from the University of Oxford through the NIH-Oxford-Cambridge Scholars Program.
Advanced imaging is becoming commonplace in modern medicine to assist in the diagnosis and treatment of many diseases. John's work focuses on combining 3d MRI and ultrasound images in order to improve the diagnosis and monitoring of cardiac conditions as well as guidance of cardiac procedures.
A growing number of cardiac procedures are being performed percutaneously -- using minimally-invasive techniques to reach the heart without the dangers of "open-heart" surgery. A challenge of percutaneous treatment is guidance: because the physician cannot directly see their instruments, he or she relies on advanced imaging for guidance. Although MR images have high spatial resolution and excellent tissue discrimination, there are significant difficulties associated with acquiring MR images during a procedure. Ultrasound, on the other hand, offers exceptional temporal resolution and is easy to acquire during a procedure, though the quality of images is not as high.
John is working to develop techniques that will take MR images acquired before a cardiac procedure, and register them to ultrasound images acquired during that procedure. This will allow physicians to see a high-quality, real-time image during the procedure. Though the image is based on the pre-operative MR image, it will be altered to match information from real-time ultrasound information. This will allow interventional cardiology and electrophysiology procedures that are more accurate and carry less risk to the patient.
JE McManigle, RV Stebbing, JA Noble. Modified Hough Transform for Left Ventricle Myocardium Segmentation in 3-D Echocardiogram Images, in Proceedings of International Symposium on Biomedical Imaging, 2-5 May 2012, Barcelona. IEEE.
RV Stebbing, JE McManigle, JA Noble. Interpreting Edge Information for Improved Endocardium Delineation in Echocardiograms, in Proceedings of International Symposium on Biomedical Imaging, 2-5 May 2012, Barcelona. IEEE.
MJ Shuster, A Vaish, HH Cao, AI Guttentag, JE McManigle, AL Gibb, MM Martinez, RM Nezarati, JM Hinds, W-S Liao, PS Weiss, AM Andrews. Patterning small-molecule biocapture surfaces: microcontact insertion printing vs. photolithography. Chem. Commun., 2011, 47, 10641-10643
NT Colburn, JE McManigle, P Singal, J Balow Jr, D Mogul, K Zaal, HW Sun, B Barham, JJ Chae, D Kastner. Dissecting Inflammatory and Chemotactic Pathways in Familial Mediterrean Fever [abstract]. ISSAID Conf; 2008; Rome. p 10, abstract 199
NT Colburn, JJ Chae, K Zaal, J Balow Jr, JE McManigle, I Aksentijevich, HW Sun; Dysfunctional Chemotaxis in Familial Mediterranean Fever [abstract]. Arthritis Rheum 2009;60 Suppl 10 :1481
John can be contacted at john.mcmanigle<at>wolfson.ox.ac.uk.
His CV is available here.