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We were involved in an EU project (IMPPACT), where we developed new models of the heat treatment by Radio Frequency Ablation (RA) of liver cancer. The success rate of such treatment can be very high, but is strongly dependent upon the expertise of the attending clinician. By developing a tool that can simulate the treatment and using this to optimise the treatment, we aim to improve the success rate for this minimally invasive procedure. We have developed new models of both tissue bio-heat and cell thermal response behaviour, based on experimental data. We are currently working to link these to large-scale measurements and validate them on a multi-scale level in order to provide more accurate predictions of thermal ablation and hence influence better clinical practice. We will soon start a follow-up project (Go-Smart) that will broaden the scope of this to other therapies and provide more widely applicable clinical tools.