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Monitoring for health

Fetal and neonatal functional imaging

Fetal and neonatal functional imagingWhy do some small babies thrive when they are born and others do not?

We will study Intra-Uterine Growth Restricted (IUGR) babies in the womb and then during the first year of life to understand why this is the case. We will use ultrasound imaging and MRI to assess brain and liver function, so that we can characterize intrauterine organ fetal growth according to neonatal functional outcome. This should provide the evidence base for the development of new intrauterine treatments and interventions optimized for each baby and their rate of development in the womb.

IBME team: Prof. J. Alison Noble, Dr Julia Schnabel, Dr Sylvia Rueda, Dr Caroline Knight, Dr Anil Kopuri

Clinical collaborators: Mr Stephen Kennedy, Dr Jose Villar (NDOG), Prof. Andrew Wilkinson, Dr Peter Sullivan (Paediatrics), Dr Gerardine Quaghebeur (Neuro-Radiology), Mr Aris Papageorghiou (NDOG)

Self-management of long-term conditions

Self-management of long-term conditionsPeople, especially young people, with a mild or moderate form of a long-term condition such as asthma or diabetes expect to lead a normal life and do not want to change their routine or be confined to one specified location for self-monitoring. Mobile phone technology provides the right technology for mobility and integration into daily life, delivering personalised healthcare content to the individual’s handset. Between 2000 and 2030, the number of people with diabetes will increase from 171 million to 366 million, 298 million of whom will be in poor countries. Yet 70% of the 3.3 billion mobile phone subscribers in the world today are in developing countries. The next decade gives us a unique opportunity to develop telehealth technology based on mobile phones for application to the developing world.

  • Telemedicine in the developing world: chronic diseases
    IBME team: Prof. Lionel Tarassenko, Mr Arvind Raghu, Mr Mauricio Villarroel, Dr Kirsty Bobrow
    Clinical collaborators: Dr Andrew Farmer, Prof. Andrew Neil (DPHPC)

  • Telemedicine in the developed world: vital sign monitoring in the home
    IBME team: Prof. Lionel Tarassenko, Dr David Clifton
    Clinical collaborators: Dr James Price (NDM) and Dr Chris Pugh (NDM)

Neurodegenerative diseases (Deep-brain Simulation)

Deep-brain SimulationThe main aim of this research is to improve Deep Brain Stimulation (DBS) treatment for movement disorders and central neuropathic pain, by developing a demand neuro-stimulator that will adapt stimulation to the individual pathological brain oscillations recorded in each patient. This will personalise therapy for around 2 million patients (Europe and US) with intractable movement disorders who need DBS, by tailoring stimulation to their needs. By only stimulating when required this will improve outcome and save power. Ultimately we hope to extend such tailored DBS treatments to a wide range of other conditions characterised by abnormal oscillations, such as epilepsy, central neuropathic pain and depression.

IBME team: Dr Penny Smith, Prof. John Stein (DPAG), Dr Hamid Mohseni

Clinical collaborators: Prof. Tipu Aziz (Neurosurgery)


Monitoring team

Dr Aris Papageorghiou, Dr Hamid Mohseni, Dr David Clifton, Prof. Lionel Tarassenko, Dr John Stuart-Brittain (top)
Dr Maria Murgasova, Dr Penny Smith, Dr Sylvia Rueda, Dr Peter Sullivan, Prof. Alison Noble, Dr Julia Shnabel, Dr Andrew Wilkinson (left to right)