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Professor Eleanor Stride

Statutory Professor of Biomaterials

Dr Eleanor StrideContact

Email:
Phone: +44(0)1865 617 747
Mailing address: Institute of Biomedical Engineering, Old Road Campus Research Building, University of Oxford, Oxford OX3 7DQ, UK

Academic Background

Eleanor Stride holds a B.Eng. and Ph.D. from University College London. Following the completion of her PhD in 2005 She was appointed to a Royal Academy of Engineering and EPSRC Research Fellowship and subsequently a Readership in 2010. She joined the Institute of Biomedical Engineering in Oxford in October 2011, becoming a full Professor in 2014. 

Her research is focused in two complementary areas: 

(1) Drug delivery systems engineering 

  • Advanced encapsulation methods for the fabrication of drug carriers
  • Controlled release and biophysics of therapeutic delivery
  • Theranostics and treatment monitoring   

 

2) Biomedical ultrasonics

  • Engineering microbubble agents for diagnostic and therapeutic applications
  • Physics of cavitation in high intensity focused ultrasound
  • Biophysical effects of ultrasound


Awards and Prize

  • Blavatnik Awards for Young Scientists, UK Life Sciences finalist (2020)
  • 100 Most Influential Women in Engineering (https://www.ft.com) (2019)
  • Fellowship of the Acoustical Society of America (2018)
  • Fellowship of the Royal Academy of Engineering (2017)
  • 50 Most Influential Women in Engineering (http://www.wes.org.uk/we50) (2016)
  • The Institute of Engineering and Technology (IET) AF Harvey prize (2014)
  • The Acoustical Society of America Bruce Lindsay Award (2013)
  • The Worshipful Company of Armourers and Brasiers Venture Prize (2010)
  • The Leverhulme Trust Philip Leverhulme Prize (Biomedical Engineering) (2009)
  • EPSRC & Journal of the Royal Society Interface Award (best paper for the period 2004-2009) (2009)
  • Parliamentary Science, Engineering & Technology for Britain Engineering Medal (2009)
  • Royal Society Brian Mercer Innovation Feasibility Award (2009)
  • Royal Academy of Engineering EPSRC Research Fellowship (2005-2010) 

Selected Recent Publications (complete list of publications) 

  • V. Pereno*, J. Lei, D. Carugo, E. Stride. Microstreaming inside model cells induced by ultrasound and microbubbles. Langmuir DOI: 10.1021/acs.langmuir.0c00536 (2020)
  • E. Beguin*, M. Gray, H. Nesbitt, Y. Sheng, S. Kamila, J. Owen*, L. Barnsley*, A.P. McHale, J.F. Callan, E. Stride. Targeted Delivery of Sonodynamic Therapy using a Combined Magnetic Acoustic Device for the Treatment of Pancreatic Cancer Journal of Controlled Release 317, 23-33 (2020)
  • E. Beguin*, S. Shrivastava*, N. Dezhkunov, A. McHale, J. Callan, E. Stride. Direct evidence of multi-bubble sonoluminescence using therapeutic ultrasound and microbubbles. ACS Applied Materials & Interfaces, 11, 19913−19919 (2019)
  • E. Stride and C. Coussios. Nucleation, Mapping and Control of Cavitation for Drug Delivery. Nature Reviews Physics DOI: 10.1038/s42254-019-0074-y (2019)
  • H. Horsley, J. Owen, D. Carugo, E. Stride, J. Rohn. Ultrasound-activated microbubbles as a novel intracellular drug delivery system for urinary tract infection. Journal of Controlled Release 301, 166-175 (2019)
  • E. Beguin*, L. Bau*, S. Shrivastava, E. Stride. Comparing strategies for magnetic functionalisation of microbubbles. ACS Applied Materials and Interfaces 11 (2), 1829-1840 (2019)
  • C. Mannaris, B. Teo*, A. Seth*, L. Bau*, C. Coussios, E. Stride Gas-Stabilizing Gold Nanocones for Acoustically Mediated Drug Delivery. Advanced Healthcare Materials 1800184 (2018)
  • V. Pereno*, M. Aron*, O.Vince*, C. Mannaris, A. Seth*, M. de Saint Victor*, G. Lajoinie, M. Versluis, C. Coussios, D. Carugo, E. Stride. Layered acoustofluidic resonators for the study of the physical and biological effects of acoustic cavitation. Biomicrofluidics 12: 034109 (2018) (#)
  •  L. Barnsley*, M. Gray, E. Beguin*, D. Carugo*, E. Stride. A combined magnetic-acoustic device for simultaneous, co-aligned application of magnetic and ultrasonic fields. Advanced Materials Technologies 1800081 (2018)
  •  H. Nesbitt, Y. Sheng, S. Kamila, K. Logan, K. Thomas, B. Callan, M. Taylor, M. Love, D. O’Rourke, P. Kelly, E. Beguin*, E. Stride, A. McHale, J. Callan. Gemcitabine loaded Microbubbles for Targeted Chemo-Sonodynamic Therapy of Pancreatic Cancer. Journal of Controlled Release 279: 8-16 (2018)
  • J. Owen*, C. Crake*, R.Browning*, J. Lee*, D. Carugo*, E. Stride. A versatile method for the production of magnetic microbubbles for targeted drug delivery. Drug Delivery and Translational Research 8: 342–356 (2018)
  • D. Carugo, M. Aron, E. Sezgin, J. Bernardino de la Serna, M. Kuimova, C. Eggeling, E. Stride. Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles. Biomaterials 113: 105-117 (2017).
  • C. Crake, J. Owen, S. Smart, C. Coviello, C. Coussios, R. Carlisle, E. Stride. in vivo biodistribution of fluorescently-tagged MR-visible magnetic microbubbles for cavitation enhancement monitored with real time passive acoustic mapping. Ultrasound in Medicine and Biology 42:3022-3036  (2016). 
  • J. Kwan, G. Lajoinie, N. de Jong, E. Stride, M. Versluis, C. Coussios. Ultra High Speed Dynamics of Micron- Sized Inertial Cavitation from Nanoparticles. Physical Review Applied 6:044004 (2016).
  • H. Mulvana, R. Browning, Y. Ling, N. de Jong, M. Tang, R. Eckersley, E. Stride. Characterisation of Contrast Agent Microbubbles for Ultrasound Imaging and Therapy Research. IEEE Trans. Ultrasonics, Ferr, Freq. Cont. (2016 - in press 
  • D. Carugo, E. Bottaro, J. Owen, E. Stride, C. Nastruzzi. Liposome production by microfluidics: potential and limiting factors. Scientific Reports 6:25876 (2016).
  • L. Barnsley, D. Carugo, E. Stride. Optimized shapes of magnetic arrays for drug targeting applications. J. Phys. D 49: 225501 (2016). 
  • G. Lajoinie, E. Stride, I. Lentacker, I. De Cock, C. Coussios, S. Le Gac, M.Versluis. Methods review for the in-vitro study of bubble-cell interactions at all relevant timescales. Biomicrofluidics 10: 011501 (2016).
  • C. McEwan, S. Kamila, J. Owen, H. Nesbitt, M. Taylor, M. Borden, E. Stride, A. McHale and J. Callan. Combined Sonodynamic and Antimetabolite Therapy for the Improved Treatment of Pancreatic Cancer using Oxygen Loaded Microbubbles as a Delivery Vehicle. Biomaterials 80:20-32 (2016).
  • J. Owen and E. Stride. Characterisation of the Coating of Phospholipid Microbubbles by Transmission Electron Microscopy. Ultrasound in Medicine and Biology 41: 3253-3258 (2015)
  • L. Barnsley, D. Carugo, J. Owen and E. Stride. Halbach arrays consisting of cubic elements optimized for high field gradients in magnetic drug targeting applications. Phys. Med. Biol. 60: 8303-8327 (2015)
  • J. Lee, D. Carugo, C. Crake, J. Owen, M. de Saint Victor, A. Seth, C. Coussios and E. Stride. Nanoparticle-loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery. Advanced Materials 27: 5484–5492 (2015).
  • J. Kwan, S. Graham, R. Myers, E. Stride, R. Carlisle, C. Coussios. Ultrasound-induced inertial cavitation from gas stabilizing nanoparticles. Physical Review E 92: 023019
  • T. Millard, M. Endrizzi, N. Everdell, L. Rigon, F. Arfelli, R. Menk, E. Stride and A. Olivo. On the potential for transforming x-ray imaging into a functional modality through the use of microbubble contrast agents. Scientific Reports 29:12509 (2015)
  • J. Owen, P. Rademeyer, D. Chung, Q. Cheng, D. Holroyd, C. Coussios, P. Friend, Q. Pankhurst and E. Stride. Magnetic Targeting of Microbubbles against Physiologically Relevant Flow Conditions. J. Roy. Soc. Interface Focus 5: 20150001 (2015)
  • D. Carugo, J. Owen, C. Crake, J. Lee and E. Stride. Biologically and acoustically compatible chamber for studying ultrasound-mediated delivery of therapeutic compounds. Ultrasound in Medicine and Biology 41: 1927-1937 (2015)
  • C. McEwan , J. Owen , E. Stride, C. Fowley, H. Nesbitt, D. Cochrane, D. Coussios, M. Borden, A. McHale and J. Callan. Oxygen Carrying Microbubbles for Enhanced Sonodynamic Therapy of Hypoxic Tumours.  Journal of Controlled Release 203: 51–56 (2015).
  • P. Rademeyer, D. Carugo, J. Lee and E. Stride. "Microfluidic System for High Throughput Characterisation of Echogenic Particles", Lab on a Chip 15:417-28 (2015).
  •  J. Owen, P. Grove, P. Rademeyer and E. Stride."The influence of blood on targeted microbubbles", J. R. Soc. Interface 11: 20140622 (2014)