Dr Michael Gray

Senior Research Fellow in Clinical Therapeutic Ultrasound

Academic Background Dr Michael Gray

Michael joined the BUBBL group in September 2015 primarily to work on a Phase-1 clinical trial of ultrasound-mediated targeted drug delivery for treatment of liver cancer. His current research areas and interests include clinical translation of cavitation monitoring techniques and the use of sound and magnetism for targeted drug delivery.

Michael earned his doctorate from the Georgia Institute of Technology in 2015 after designing and demonstrating an ultrasonic system for deep tissue elastography. Over the preceding 23 years, Michael was a research engineer and principal investigator at Georgia Tech, working in research areas including submarine sonar, cetacean soft tissue characterization, photoacoustics, fish hearing, and non-destructive structural evaluation.

Selected Recent Publications

Gray, M.D., Elbes, D., Paverd, C., Lyka, E., Coviello, C., Cleveland, R., & Coussios, C. (2021). Dual array passive acoustic mapping for cavitation imaging with enhanced 2-D resolution. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), 647-663 https://doi.org/10.1109/TUFFC.2020.3019573

Beguin, E., Gray, M.D., Logan, K.A., Nesbitt, H., Sheng, Y., Kamila, S., Barnsley, L.C., Bau, L., McHale, A.P., Callan, J.F., and Stride, E., “Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device”, J. Controlled Release, (2020) 317(10): 22-33, doi:10.1016/j.jconrel.2019.11.013

Gray, M.D., Stride, E., and Coussios, C.C., “Snap, Crackle, Pop: Theracoustic Cavitation,” Acoustics Today 15(1), Spring 2019, https://doi.org/10.1121/AT.2019.15.1.21

Gray, M.D., Lyon, P.C., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., and Coussios, C.C., “Focused ultrasound hyperthermia for targeted drug release from thermosensitive liposomes: results from a Phase 1 Trial”, Radiology, (2019) 291:232-238, https://doi.org/10.1148/radiol.2018181445

Gray, M.D. and Coussios, C.C., “Broadband ultrasonic attenuation estimation and compensation with passive acoustic mapping”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, (2018) 65(11): 1997-2011, doi:10.1109/TUFFC.2018.2866171

Lyon, P.C., Gray, M.D., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., and Coussios, C.C., “TarDox: A Phase I trial investigating the safety and feasibility of ultrasound-triggered targeted drug delivery in liver tumours,” Lancet Oncology (2018) 19(8): 1027-1039, https://doi.org/10.1016/S1470-2045(18)30332-2

Google Scholar Link to Full Publication List: GSL

Contact

Email: michael.gray@eng.ox.ac.uk

Phone: +44(0) 1865 617 692

Mailing address:

Institute of Biomedical Engineering

Old Road Campus Research Building

University of Oxford

OXFORD

OX3 7DQ