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Dr Richard J Browning

Post-Doctoral Researcher

 

Academic Background

Richard J Browning was awarded his Ph.D. in Biophysics from Imperial College London Richard Browning(London, UK) in 2012. Over the following years, he worked as a post-doctoral research investigating the use of ultrasound and contrast agents for targeted drug delivery of gene vectors and radiolabelled antibodies at Imperial College London and King’s College London (London, UK) respectively. In 2014, Richard joined the BUBBL group at the University of Oxford to developing ultrasound contrast agents loaded with cisplatin nanoparticles for the targeted treatment of head and neck cancers.

Since 2016, Richard is involved in a Pancreatic Research Fund project investing the use of sonodynamic therapy to augment traditional or targeted chemoradiotherapy in pancreatic cancer. Other areas of interest include the development of ultrasound compatible 3D phantoms for cell based drug delivery work, and a collaboration investigating the use of ultrasound for targeted delivery of chemotherapy constructs in bladder cancer.”

Journal Paper Publications:

Owen, J., Kamila, S., Shrivastava, S., Carugo, D., Bernardino de la Serna, J., Mannaris, C., Pereno, V., Browning, R.J., Beguin, E., McHale, A.P., Callan, J.F., Stride, E., “The role of PEG-40-stearate in the production, morphology and stability of microbubbles.” Langmuir, (2018) http://dx.doi.org/10.1021/acs.langmuir.8b02516 (Accepted for publication)

Ruan, J-R., Hsu, J-W., Browning, R.J., Stride, E., Yildiz, Y.O., Vojnovic, B., Kiltie, A.E., “Mouse Models of Muscle-invasive Bladder Cancer: Key Considerations for Clinical Translation Based on Molecular Subtypes.” Eur Urol Oncol, (2018) http://dx.doi.org/10.1016/j.euo.2018.08.014 (Article in Press)

Browning, R.J, Stride E., “Microbubble-Mediated Delivery for Cancer Therapy.” Fluids 3(4): 74-85 (2018). https://dx.doi.org/10.3390/fluids3040074

Stride, E, Mulvana, H., Rademeyer, P., Carugo, D., Owen, J., Browning, R.J., Tang, M.X., Eckersley, R.J., “Characterisation of Functionalised Microbubbles for Ultrasound Imaging and Therapy.” Book Chapter in: The Micro-World Observed by Ultra High-Speed Cameras, Ed.: Tsuji, K., Pub: Springer (2018). https://dx.doi.org/10.1007/978-3-319-61491-5_18

Owen, J., Crake, C., Lee, J.Y., Carugo, D., Beguin, E., Khrapichev, A., Browning, R.J., Sibson, N., Stride, E., “A versatile method for the preparation of particle-loaded microbubbles for multimodality imaging and targeted drug delivery.” Drug Deliv Transl Res 8(2): 342-356 (2018). http://dx.doi.org/10.1007/s13346-017-0366-7

Browning, R.J., Reardon P.J.T., Parhizkar M., Pedley R.B., Edirisinghe M., Knowles J.C., Stride E., “Drug Delivery Strategies for Platinum Based Chemotherapy.” ACS Nano 11(9): 8560-8578 (2017). http://dx.doi.org/10.1021/acsnano.7b04092

Aron, M., Browning, R.J., Carugo, D., Sezgin, E., Bernardino de la Serna, J., Eggeling, C., Stride, E., “Spectral imaging toolbox: Segmentation, hyperstack reconstruction, and batch processing of spectral images for the determination of cell and model membrane lipid order.” BMC Bioinformatics 18(1):254 (2017). http://dx.doi.org/10.1186/s12859-017-1656-2

Parhizkar, M., Reardon, P.J.T., Knowles, J.C., Browning, R.J., Stride, E., Pedley, R.B., Grego, T., Edirisinghe, M., “Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles.” Mater Des 126: 73-84 (2017). https://dx.doi.org/10.1016/j.matdes.2017.04.029

Reardon, P.J.T., Parhizkar, M., Harker, A.H., Browning R.J., Vassileva, V., Stride, E., Pedley, R.B., Edirisinghe, M., Knowles, J.C., “Electrohydrodynamic fabrication of core-shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment.” Int J Nanomedicine 12: 3913-3926 (2017). http://dx.doi.org/10.2147/IJN.S134833

Mulvana, H., Browning, R.J., Luan, Y., Jong, N. de, Tang, M.X., Eckersley, R.J. Stride, E., “Characterization of Contrast Agent Microbubbles for Ultrasound Imaging and Therapy Research.” IEEE Trans Ultrason Ferroelectr Freq Control 64(1): 232-251 (2017). http://dx.doi.org/10.1109/TUFFC.2016.2613991

Parhizkar, M., Reardon, P.J.T., Knowles, J.C., Browning, R.J., Stride, E., Pedley, R.B., Harker, A.H., Edirisinghe, M., “Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery”, Nanomedicine 12(7): 1919-1929 (2016). http://dx.doi.org/10.1016/j.nano.2016.05.005

Carugo, D., Lee, J.Y., Pora, A., Browning, R.J., Capretto, L., Nastruzzi, C., Stride, E., “Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (μMi-REM) technique”, Biomed Microdevices 18(4): 1-10 (2016). http://dx.doi.org/10.1007/s10544-015-0027-x

Christensen-Jeffries, K., Browning, R.J., Tang, M.-X., Dunsby, C., Eckersley, R.J., “In Vivo Acoustic Super-Resolution and Super-Resolved Velocity Mapping Using Microbubbles”, IEEE Trans Med Imaging 34(2):433-440. (2015). http://dx.doi.org/10.1109/TMI.2014.2359650

Browning, R.J., Rajkumar, V., Pedley, R.B., Eckersley, R.J., Blower, P.J., “Prospects for enhancement of targeted radionuclide therapy of cancer using ultrasound”, J Labelled Compd Rad 57(4): 279–284 (2014). http://dx.doi.org/10.1002/jlcr.3157

Mulvana, H., Browning, R.J., Tang, M.-X., Hajnal, J.V., Eckersley, R.J., “Albumin coated microbubble optimization: Custom fabrication and comprehensive characterization”, Ultrasound Med Biol 38(9): 1599-1607 (2012). http://dx.doi.org/10.1016/j.ultrasmedbio.2012.05.002

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J., Eckersley, R.J., “Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo”, Ultrasound Med Biol 38(6): 1067-1077 (2012). http://dx.doi.org/10.1016/j.ultrasmedbio.2012.02.020

Browning, R.J., Mulvana, H., Tang, M.-X., Hajnal, J.V., Wells, D.J., Eckersley, R.J., “Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection”, Ultrasound Med Biol 37(9): 1531-1537 (2011). http://dx.doi.org/10.1016/j.ultrasmedbio.2011.05.019

Conference Presentations:

‘Temperature-controlled acoustofluidic production of microbubble contrast agents with enhanced stability and monodispersity’, The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018), Kaohsiung, Taiwan, 2018

‘Investigation of Combined Sonodynamic and Radiotherapy for Pancreatic Cancer’, IEEE International Ultrasonics Symposium, Kobe, Japan, 2018

 ‘Ultrasound enhanced delivery of cisplatin loaded nanoparticles’, The 3rd Joint Meeting of the Acoustical Society of America and the European Acoustics Association, Boston, USA, 2017

‘Spectral imaging of lipid packing in microbubbles’, 22nd Symposium on Ultrasound Contrast Imaging, Rotterdam, Netherlands, 2017

‘Spectral imaging of microbubbles’, Nanoparticles/microbubbles: Drug carriers for enhanced drug delivery, London, United Kingdom, 2016

‘The effect of DNA loading on ultrasound and microbubble mediated transfection in vivo’, International Congress on Ultrasonics, Singapore, Singapore, 2013

‘DNA loaded albumin microbubbles for ultrasound & microbubble mediated gene transfection in vivo’, 18th Symposium on Ultrasound Contrast Imaging, Rotterdam, Netherlands, 2013

‘Using ultrasound and microbubbles for gene transfection in the murine heart’, Invited talk, Fourth Preclinical Ultrasound Imaging day, Edinburgh, United Kingdom, 2012

‘The effect of glucosamine on the acoustic and binding properties of albumin-based microbubbles (work in progress)’, IEEE International Ultrasonics Symposium, Dresden, Germany, 2012

‘Characterisation of novel DNA-loading albumin-based microbubbles for improved gene transfection (work in progress)’, BMUS Annual Science Meeting and Exhibition, Telford, United Kingdom, 2012

 ‘Effect of microbubble shell components on ultrasound and microbubble mediated gene transfection in vivo’, IEEE International Ultrasonics Symposium, Orlando, USA, 2011

‘New formulations of albumin and dextrose-based microbubbles for improved in vivo gene transfection’, BMUS Annual Science Meeting and Exhibition, Brighton, United Kingdom, 2011

‘Effect of albumin concentration on ultrasound and microbubble mediated gene transfection in vivo: a preliminary in vitro and in vivo investigation’, 16th Symposium on Ultrasound Contrast Imaging, Rotterdam, Netherlands, 2011

‘Effect of needle gauge on microbubble mediated cell transfection in vivo’, BMUS Annual Science Meeting and Exhibition, Brighton, United Kingdom, 2010

Contact:

Email: richard.browning@oncology.ox.ac.uk

Phone: +44(0)1865 617659

Mailing address: Department of Oncology, Old Road Campus

Research Building, University of Oxford, Oxford OX3 7DQ, UK