Personal tools

Dr Richard Browning

Post-Doctoral Researcher

Academic Background:Richard Browning2

Richard J Browning was awarded his Masters in Biochemistry degree (MBiochem) with honours from University of Bath (Bath, UK) in 2007; and in 2012, received his Ph.D. in Biophysics from Imperial College London (London, UK). He continued in 2012 at Imperial College London as a postdoctoral researcher, before moving to King’s College London (London, UK) in 2013 for a second postdoctoral research position. In 2014, Richard joined the BUBBL group at the University of Oxford.

From 2009 to 2012, Richard investigated the factors that influence the effectiveness of ultrasound mediated delivery (UMD) by developing novel ultrasound contrast agents (UCAs) with varying acoustic and behavioural properties. He continued this work in 2012; creating transfection-specific UCAs and attempting to optimise delivery-specific UCA parameters. In 2013, he studied the potential use of UMD to improve delivery of radioimmunotherapy particles for the treatment of breast cancer. His current work is focused on developing UCAs loaded with cisplatin nanoparticles for the targeted treatment of head and neck cancers.

 

Journal Paper Publications:

M. Parhizkar, P.J.T. Reardon, J.C. Knowles, R.J. Browning, E. Stride, B.R. Pedley, A.H. Harker, M. Edirisinghe, “Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery”, Nanomedicine 12(7): 1919-1929 (2016). http://dx.doi.org/10.1016/j.nano.2016.05.005

D. Carugo, J.Y. Lee, A. Pora, R.J. Browning, L. Capretto, C. Nastruzzi, E. Stride, “Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (μMi-REM) technique”, Biomed Microdevices 18(4): 1-10 (2016). http://dx.doi.org/10.1007/s10544-015-0027-x

K. Christensen-Jeffries, R.J. Browning, M.-X. Tang, C. Dunsby and R.J. Eckersley, “In Vivo Acoustic Super-Resolution and Super-Resolved Velocity Mapping Using Microbubbles”, IEEE Trans. Med. Imaging 34(2):433-440. (2015). http://dx.doi.org/10.1109/TMI.2014.2359650

R.J. Browning, V. Rajkumar, R.B. Pedley, R.J. Eckersley and P.J. Blower, “Prospects for enhancement of targeted radionuclide therapy of cancer using ultrasound”, J. Labelled Compd. Rad. 57(4): 279–284 (2014). http://dx.doi.org/10.1002/jlcr.3157

H. Mulvana, R.J. Browning, M.-X. Tang, J.V. Hajnal and R.J. Eckersley, “Microbubble optimization: Custom fabrication and comprehensive characterization”, Ultrasound Med. Biol. 38(9): 1599-1607 (2012). http://dx.doi.org/10.1016/j.ultrasmedbio.2012.05.002

R.J. Browning, H. Mulvana, M.-X. Tang, J.V. Hajnal, D.J. Wells and R.J. Eckersley, “Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo”, Ultrasound Med. Biol. 38(6): 1067-1077 (2012). http://dx.doi.org/10.1016/j.ultrasmedbio.2012.02.020

R.J. Browning, M.-X. Tang and R.J. Eckersley, “The effect of glucosamine on the acoustic and binding properties of albumin-based microbubbles (work in progress)”, Ultrasonics Symposium (IUS), 2012 IEEE International 2294-2297 (2012). http://dx.doi.org/10.1109/ULTSYM.2012.0573

R.J. Browning, H. Mulvana, M.-X. Tang, J.V. Hajnal, D.J. Wells and R.J. Eckersley, “Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection”, Ultrasound Med. Biol. 37(9): 1531-1537 (2011). http://dx.doi.org/10.1016/j.ultrasmedbio.2011.05.019

H. Mulvana, R.J. Eckersley, R. Browning, J.V. Hajnal, E. Stride, T. Barrack, Q. Pankhurst, M.-X. Tang and D.J. Wells, “Enhanced gene transfection in vivo using magnetic localisation of ultrasound contrast agents: Preliminary results”, Ultrasonics Symposium (IUS), 2010 IEEE 670-673 (2010). http://dx.doi.org/10.1109/ULTSYM.2010.5935952

 

Conference Presentations:

R.J. Browning, D. Carugo, P. Rademeyer, E. Sezgin, J. Bernardino de la Serna, C. Eggeling and E. Stride, (2016) “Spectral Imaging of Microbubbles”, Nanoparticles/microbubbles: Drug carriers for enhanced drug delivery, London

R.J. Browning, M.-X. Tang and R.J. Eckersley, (2013) “The effect of DNA loading on ultrasound and microbubble mediated transfection in vivo”, 2013 International Congress on Ultrasonics, Singapore

R.J. Browning, M.-X. Tang and R.J. Eckersley, (2013) “DNA loaded albumin microbubbles for ultrasound & microbubble mediated gene transfection in vivo”, 18th Symposium on Ultrasound Contrast Imaging, Rotterdam, The Netherlands

R.J. Browning, (2012) “Using ultrasound and microbubbles for gene transfection in the murine heart”, Invited talk, Fourth Preclinical Ultrasound Imaging day, Edinburgh, UK

R.J. Browning, M.-X. Tang and R.J. Eckersley, (2012) “The effect of glucosamine on the acoustic and binding properties of albumin-based microbubbles (work in progress)”, IEEE International Ultrasonics Symposium, Dresden, Germany

R.J. Browning, M.-X. Tang and R.J. Eckersley, (2012) “Characterisation of novel DNA-loading albumin-based microbubbles for improved gene transfection (work in progress)”, BMUS Annual Science Meeting and Exhibition, Telford, UK

R.J. Browning, H. Mulvana, M.-X. Tang, J.V. Hajnal, D.J. Wells and R.J. Eckersley, (2011) “Effect of microbubble shell components on ultrasound and microbubble mediated gene transfection in vivo”, IEEE International Ultrasonics Symposium, Orlando, USA

R.J. Browning, H. Mulvana, M.-X. Tang, J.V. Hajnal, D.J. Wells and R.J. Eckersley, (2011) “New formulations of albumin and dextrose based microbubbles for improved in vivo gene transfection”, BMUS Annual Science Meeting and Exhibition, Brighton, UK

R.J. Browning, H. Mulvana, M.-X. Tang, J.V. Hajnal, D.J. Wells and R.J. Eckersley (2011) “Effect of albumin concentration on ultrasound and microbubble mediated gene transfection in vivo: a preliminary in vitro and in vivo investigation”, 16th Symposium on Ultrasound Contrast Imaging, Rotterdam, The Netherlands

R.J. Browning, H. Mulvana, M.-X. Tang, D.J. Wells and R.J. Eckersley, (2010) “Effect of needle gauge on microbubble mediated cell transfection in vivo”, BMUS Annual Science Meeting and Exhibition, Brighton, UK

 

Contact:

Email: richard.browning@eng.ox.ac.uk

Phone: +44(0)1865 617661

Mailing address: Institute of Biomedical Engineering, Old Road Campus

Research Building, University of Oxford, Oxford OX3 7DQ, UK