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Professor Robin O. Cleveland

Professor of Engineering Science; Tutorial Fellow at Magdalen College, Oxford

Professor Robin ClevelandContact

Phone: +44(0)1865 617 737
Mailing address: Institute of Biomedical Engineering, Old Road Campus Research Building, University of Oxford, Oxford OX3 7DQ, UK

Academic Background

Robin Cleveland is Professor of Engineering Science at the University of Oxford and Tutorial Fellow at Magdalen College, Oxford.  He received the PhD degree in Mechanical Engineering from the University of Texas at Austin where his doctoral research was on sonic boom propagation in the atmosphere.  At the completion of his PhD he was award the F.V. Hunt Fellowship of the Acoustical Society of America which he carried out at the University of Washington in Seattle studying shock wave lithotripsy – breaking of kidney stones by shock waves.  After two years in Seattle he joined the faculty at Boston University where he remained for fourteen years rising to the rank of Professor of Mechanical Engineering.  In 2011 he joined BUBL.  He carries out research in nonlinear acoustics with particular application to biomedical ultrasound.  Areas of research include: shock wave lithotripsy, high intensity focused ultrasound surgery for thermal ablation,  nonlinear distortion of B-mode diagnostic ultrasound, the development of shelled microbubble for ultrasound theranostics (targeted imaging and drug-delivery).

Awards and Prizes


  • Invited Speaker, Frontier Acoustics Symposium, Shenhzen, China (2017).
  • Royal College of Surgeons of Edinburgh, Guest Lecturer at World Congress of Endourology, London (2015).
  • Plenary Speaker, International Symposium on Nonlinear Acoustics, Lyon, France (2015).
  • Keynote Speaker, Joint 11th Congrès Français d'Acoustique and the Annual Institute of Acoustics Meeting (2012).
  • Paper of the Year IEEE Trans. on UFFC (2006).
  • Teacher of the Year, Mechanical Engineering, Boston University (2009). 
  • ASA Bruce Lindsey Award (2000) 
  • ASA Hunt Post-Doctoral Fellowship in Acoustics (1995-6).

Selected Recent Publications

  • V. Suomi, J. Jaros, B. Treeby, R. O. Cleveland, High-intensity focused ultrasound therapy in the kidney: a simulation study, IEEE Trans. on Biomedical Engineering 65: 969-979 (2018).
  • Dongli Li, Antonio Pellegrino, Andre Hallack, Nik Petrinic, Antoine Jerusalem, Robin O. Cleveland, “Characterisation of single cell response to shock waves and in silico optimisation of shock wave-mediated therapy"  Biophysical Journal 114:1433-1439 (2018). 
  • Chad A. Tagge,Andrew M. Fisher,Olga V. Minaeva, Amanda Gaudreau-Balderrama, Juliet A. Moncaster,Xiao-Lei Zhang,Mark W. Wojnarowicz,Noel Casey, Haiyan Lu, Olga N. Kokiko-Cochran,Sudad Saman, Maria Ericsson,Kristen D. Onos, Ronel Veksler, Vlad Senatorov, Asami Kondo, Xiao Z. Zhou, Omid Miry, Linnea R. Vose, Katisha R. Gopaul, Chirag Upreti, Christopher J. Nowinski, Robert C. Cantu, Victor E. Alvarez, Janusz Konrad, James A. Hamilton, Ning Hua,Yorghos Tripodis, Andrew T. Anderson, Gareth R. Howell, Daniela Kaufer, Garth F. Hall, Kun P. Lu, Richard M. Ransohoff,Robin O. Cleveland,Neil W. Kowall,Bertrand R. Huber, Thor D. Stein, Bruce T. Lamb, William C. Moss, Alon Friedman, Patric K. Stanton, Ann C. McKee, Lee E. Goldstein  Concussion, Microvascular Injury, and Phosphorylated Tauopathy in Young Athletes after Impact Head Injury and an Impact Concussion Mouse Model, Brain 141:422-458 (2018).
  •  V.Suomi, J. Jaros, B. Treeby, R.O. Cleveland. Full modelling of high-intensity focused ultrasound and thermal heating in the kidney using realistic patient models. IEEE Transactions on Biomedical Engineering, 99:1-1 (2017)
  • W. Devlies, H.W.Cui, D.J. Stevens, S. Ravenscroft, H. Heers, A. Freidin, R.O. Cleveland, B.W. Turney, “CT Texture Analysis of Renal Stones Predicts Ease of Fragmentation with Shock Wave Lithotripsy,” In press J. Endourology (2017).
  • L.Zhang, Zesheng Zhang, John Jasa, Dongli Li, Robin O. Cleveland, Mehrdad Negahban, and Antoine Jerusalem, "Molecular dynamics simulations of heterogeneous cell membranes in response to uniaxial membrane stretches at high loading rates" Nature Scientific Reports 7, Art No 8316 (2017)
  • M.T. Adams, R.O. Cleveland, R. A. Roy, “A Modeling-Based Design and Assessment of an Acousto-Optic Guided High-Intensity Focused Ultrasound System” J. Biomed. Opt. 22(1), 017001 (2017).
  • S.Nwokeoha, R. Carlisle, R.Cleveland, The Application of Clinical Lithotripter Shock Waves on RNA Nucleotide Delivery to Cells, Ultrasound Med Biol 42:2478-2492 (2016).
  • V. Suomi, Y. Han, Yang; D. Edwards, E. Konofagou, R. O. Cleveland, “The effect of temperature dependent tissue parameters on acoustic radiation force induced displacements" Physics Med Biol 61:7427–7447 (2016).
  • S.R. Harrogate, L.M.S. Yick, J.C. Williams Jr., R.O. Cleveland, B.W. Turney, Quantification of the range of motion of kidney and ureteric stones during shockwave lithotripsy in conscious patients.  J. Endourology 30(4): 406-410 (2016).
  • S. R. Faragher, R. O. Cleveland, S. Kumar, O.J. Wiseman and B. W. Turney In-vitro assessment of clinical shock wave lithotripsy technologies, J. Endourology 30(5): 560-565 (2016).
  • S. Nwokeoha, R. Carlisle, R. O. Cleveland, The Application of Clinical Lithotripter Shock Waves on RNA Nucleotide Delivery to Cells, Ultrasound Med Biol 42:2478-2492 (2016).
  • S. Qiao, E. Jackson, C. C. Coussios, R. O. Cleveland, Simulation of nonlinear propagation of biomedical ultrasound using PZFlex and the KZK Texas code,  J. Acoust. Soc. Am. 140 (3): 2039 (2016).
  • V. Suomi, Y. Han, D. Edwards, E. Konofagou,,R.O. Cleveland, “The effect of temperature dependent tissue parameters on acoustic radiation force induced displacements" Accepted Physics Med Biol (2016).
  • V. Suomi, D. Edwards, R.O. Cleveland, Optical quantification of harmonic acoustic radiation force excitation in a tissue-mimicking phantom, Ultrasound in Med. Biol. 41: 3216-32 (2015)
  • Y. Park, T. A. Pham, C. Beigie, M. Cabodi, R. O. Cleveland, J. O. Nagy, and J. Y. Wong, Micro-Oil Droplets with Polymerizable Lipid Coating as Potential Drug Carriers, Langmuir 31:9762-70 (2015).
  • M. T. Adams, Q. Wang, R. O. Cleveland and R. A. Roy, Thermal dose dependent optical property changes of ex vivo chicken breast tissues between 500 and 1100 nm, Physics in Medicine and Biology 59(13): 3249-60 (2014).
  • C. Jensen, R.O. Cleveland, C-C Coussios, Real-time temperature estimation and monitoring of HIFU ablation through a combined modeling and passive acoustic mapping approach, Physics in Medicine and Biology, 58: 5833-5850  (2013).
  • L. E. Goldstein, A. M. Fisher, C. A. Tagge, X.-L. Zhang, L. Velisek, J. A. Sullivan, C. Upreti, J.M. Kracht,  M. Ericsson, M. Wojnarowicz,  C. J. Goletiani, G. M. Maglakelidze, N. Casey, J. A. Moncaster, O Minaeva, R.D. Moir, C.J. Nowinski, R.A. Stern, R.C. Cantu, J. Geiling, J. K. Blusztajn, B. L. Wolozin, T. Ikezu, T.D. Stein, A.E. Budson,  N.W. Kowall, D. Chargin, A. Sharon, S. Saman, G.F. Hall, W.C. Moss, R. O. Cleveland, R. E. Tanzi, P. K. Stanton, A, C. McKee “Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model,” Science Translational Medicine 4(134):1—16 (2012) PMCID: PMC3739428.
  • Y. Park, A.C. Luce, R.D. Whitaker, B. Amin, M. Cabodi, R.J, Nap, I Szleifer, R.O. Cleveland, J.O. Nagy J.Y. Wong, “Tunable diacetylene polymerized shell microbubbles as ultrasound contrast agents,” Langmuir 28: 3766−3772 (2012) PMCID: PMC3302155.
  • J. J. Rassweiler, T. Knoll, Kai-Uwe Köhrmann, J. A. McAteer, J. E. Lingeman, R. O. Cleveland, M. R. Bailey, C. Chaussy, “Shock wave technology and application – an update,” Eur. Urol. 59:784-796 (2011). 
  • B. Draudt and R. O. Cleveland, “Impact Of Nonlinear Distortion On Acoustic Radiation Force Imaging,” Ultrasound. Med. Biol. 37: 1874-1883 (2011).
  • M. Averiyanov, P. Blanc-Benon, R.O. Cleveland, and V. Khokhlova, “Nonlinear and diffraction effects in the propagation of shock N-waves in randomly inhomogeneous moving media,” J. Acoust. Soc. Am. 129:1760-1772 (2011).
  • P. Lai, J. R. McLaughlan, A. B. Draudt, T. W. Murray, R.O. Cleveland and R. A. Roy, “Real time monitoring of high intensity focused ultrasound lesion formation using acousto-optic sensing” Ultrasound. Med in Biol, 37: 239-252 (2011).
  •  N. J. Manzi, P. V. Chitnis, R.G. Holt, R.A. Roy, R. O. Cleveland, B Riemer and M. Wendel, “Detecting cavitation in mercury exposed to a high-energy pulsed proton beam,”  J. Acoust. Soc. Am. 127(4): 2231-2239 (2010).
  • T.G. Leighton and R.O. Cleveland, “Lithotripsy,” Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224(2): 317-342 (2010).
  • J. Condliffe, H. A. Schiffter, R. O. Cleveland, C-C. Coussios, “An Acoustic Microscopy Technique to Assess Particle Size and Distribution Following Needle-free Injection,” J. Acoust. Soc. Am. 127: 2252-2261 (2010).
  •  W. J. Duncanson, K. Oum, J. R.Eisenbrey, R. O. Cleveland, M. A. Wheatley and J. Y. Wong, “Targeted binding of PEG-lipid modified polymer ultrasound contrast agents with tiered surface architecture” J. Biotechnology and Bioengineering, 106(3):501-6, (2010).
  • R.O. Cleveland, P.V. Chitnis, S.R. McClure, “Acoustic Field of a Ballistic Shock Wave Therapy Device,” Ultrasound Med. and Biol. 33:1327-1335  (2007).
  • Y. Jing and R. O. Cleveland, “Modeling the propagation of nonlinear three-dimensional acoustic beams in inhomogeneous media,” J. Acoust Soc. Am. 122:1352—1364 (2007).
  • J. Huang, J. Triedman, N. V. Vasilyev, Y. Suematsu, R. O. Cleveland, P. E. Dupont, “Imaging artifacts of medical instruments in sonographically guided interventions,” J. Ultrasound in Medicine 26:1303-1322 (2007).
  • A. Y. Ammi, R. O. Cleveland, J. Mamou, G. I. Wang, S. L. Bridal, W. D. O ’Brien, Jr, “Ultrasonic contrast agent shell rupture detected by inertial cavitation and rebound signals,” IEEE Trans. on UFFC 53:126-136 (2006).