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Regenerative Medicine

Orthopaedic conditions affect the body's mechanical system of muscles, bones and joints, giving rise to pain and loss of function, severely affecting daily activities. Building on the success of the mechanical analysis of this system in advancing orthopaedic healthcare there is ongoing work to develop an understanding that integrates the complex interaction of mechanics and biology at the cell and tissue level with knowledge of the mechanical demands of locomotion at the body and limb scale. Additionally, bio-reactor technologies are being developed to enable bone, cartilage, tendon and skin culture to grow, with the ultimate aim of bulky tissue growth from stem cell cultures and the development of novel monitoring techniques. A further area of interest is the study of cryopreservation and vitrification to preserve living cells and engineered tissues, in order to ensure their off-the-shelf availability to clinicians.