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Hua (Cathy) Ye

Current Position               Associate Professor in Engineering Science
                                        Deputy Director of CRMI Technology Centre

College                            Fellow, Linacre College

Contact Information         Institute of Biomedical Engineering
                                        Department of Engineering Science
                                        Old Road Campus Research Building
                                        University of Oxford
                                        Headington
                                        Oxford
                                        OX3 7DQ
                                        UK

                                        Email: hua.ye@eng.ox.ac.uk
                                        Tel: +44(0)1865 617689


Research Interests

Within the broad research area of tissue engineering and stem cell technologies, my specific research interests lie in three interconnected areas, i.e. in vitro cancer model, biomaterials and bioreactor for tissue engineering and stem cell expansion

Background

Education

2005    University College, Oxford University
           DPhil in Biochemical Engineering
           ORS Scholar & Applied Materials Research Scholar
           Thesis topic: Novel hollow fibre membrane bioreactors for growing three dimensional
           bone tissue

1998    School of Chemical Engineering, Dalian University of Technology, China
           BEng in Chemical Engineering


Work Experience

Mar 05-Sep 07       Post-doctoral Research Associate
                            Department of Chemical Engineering, Imperial College London
 

Mar 04-Feb 05       Enterprise Fellow
                            Begbroke Science Park, Oxford University

 

Funding

Project: Engineering human neural networks (BBSRC for 5 years)

Project: Development of a smart bioreactor for mammalian adherent cell expansion for application to cell therapy Grant (EPSRC First Grant (EP/H021442/1) from 1st Jan 2010 for two years)
 
Project: Development of bone-cartilage interface (EPSRC Studentship)
 
Project: Development of in vitro three-dimensional tumour models – a feasibility study (John Fell Fund, University of Oxford from 1st Oct 2008 for 18 months)
 

Teaching/Lectures

Lectures

C10 Biosystem Modelling 

C23/BME2 Tissue Engineering

B17/BME1 Biomechanics

 

Lab organisation

Tissue Engineering Lab for MSc in Biomedical Engineering

Biochemical Engineering Coursework Module

Cell characterisation for Centre for Doctoral Training in Healthcare Innovation

 

PhD Opportunities

There are PhD projects available for interested candidates within the group research activities. Informal inquiries can be directed to Dr Cathy Ye. However, PhD applications have to be done through the university website.

 

Patents

Sambu, S., Cui, Z. Ye, H., A method for cryopreserving human embryonic stem cells (hESC) without using apoptosis inhibitors, GB1110331.4 Applicant: ISIS Innovation Ltd   (2011)

Cui, Z., Triffitt, J. T., Xia, Z., Ye, H. "Method and structure for growing living organic tissue", EP1425379B1,       Applicant: ISIS Innovation Ltd   (2006)

 

Publications

Journal Papers

  1.  Mouthuy, P., El-Sherbini, Y., Cui, Z., Ye, H. Layering PLGA-based electrospun membranes and cell sheets for engineering cartilage-bone transition. J Tissue Eng Regen M, 2013, Accepted 
  2. Mouthuy, P., Crossley, A., Ye, H Fabrication of Calcium Phosphate Fibres through Electrospinning and Sintering of Hydroxyapatite Nanoparticles. Materials Letters, 106, 145-150, 2013
  3. Liu, J., Song, L., Jiang, C., Liu, Y., Ye, H., Cui, Z. Electrophysiological properties and synaptic function of mesenchymal stem cells during neurogenic differentiation - a mini-review. Inter J Artif Organs, 35(5), 323-37, 2012
  4. Sambu, S., Xu, X., Ye, H., Cui, Z. Predicting the survival rate of mouse embryonic stem cells cryopreserved in alginate. P I Mech Eng H, 225, 1092-1107, 2011
  5. Sambu, S., Schiffter, H.A., Cui, Z. Ye, H. RGDS-functionalized alginates improve the survival rate of encapsulated mouse embryonic stem cells during cryopreservation. Cryoletters, 32(5), 389-401, 2011
  6. Lim, M., Panoskaltsis, N., Ye, H., Mantalaris, A. Optimization of in vitro erythropoiesis from CD34+ cord blood cells using design of experiments (DOE). Biochem Eng J, 55, 154-61, 2011
  7. Sambu, S., Xu, X., Ye, H., Cui, Z. Overcoming Challenges in the Cryopreservation of Stem Cells in 3D Alginate Constructs. J Biotech, 150, S446-7, 2010
  8. Mouthuy, P., Ye, H., Triffitt, J.T., Oommen, G., Cui, Z. Physico-chemical characterisation of functional electrospun scaffolds for bone and cartilage tissue engineering. P I Mech Eng H, 224 (H12), 1401-14, 2010
  9. Zhu, Y., Liu, T., Ye, H., Song, K., Ma, X., Cui, Z. Enhancement of adipose-derived stem cell differentiation in scaffolds with IGF-I gene impregnation under dynamic microenvironment. Stem Cells Dev, 19, 1548-56, 2010
  10. Yue, X., Drakakis, E., Lim, M., Radomska, A., Ye, H., Mantalaris, A., Panoskaltsis, N., Cass, A. A real-time, multi-channel monitoring system for stem cell culture process. IEEE Trans Biomed Circuits Syst, 2, 66-77, 2008
  11. Radomska, A., Singhal, S., Ye, H., Lim, M., Mantalaris, A., Yue, X., Drakakis, E., Toumazou, C., Cass, A. Biocompatible ion selective electrode for monitoring metabolic activity during the growth and cultivation of human cells. Biosens Bioelectron, 24, 435-441, 2008
  12. Lim, M., Ye, H., Drakakis, E., Yue, X., Cass, A., Panoskaltsis, N., Mantalaris, A. Towards information-rich bioprocessing: generation of spatio-temporal profiles through the use of design of experiments to determine optimal number and location of sensors - an example in thermal profiles. Biochem Eng J, 40, 1-7, 2008
  13. Lim, M., Ye, H., Placzek, M., Mantalaris, A. Stem cell bioprocessing: Manufacturing cells for clinical applications. Bioworld Europe, S1, 10-13, 2007
  14. Lim, M., Ye, H., Panoskaltsis, N., Drakakis, E., Yue, X., Cass, A., Radomska, A., Mantalaris, A. Intelligent bioprocessing for haematopoietic cell cultures using monitoring and design of experiments. Biotech Adv, 25, 353-368, 2007
  15. Ye, H., Xia, Z., Ferguson D. J. P., Triffitt, J. T., Cui, Z. Studies on the use of hollow fibre membrane bioreactors for tissue generation by using rat bone marrow fibroblastic cells and a composite scaffold. J Mater Sci Mater Med, 18, 641-648, 2007
  16. Abdullah, N. S., Das, D. B., Ye, H., Cui, Z. 3D bone tissue growth in hollow fibre membrane bioreactor: implications of various process parameters on tissue nutrition. Inl J Artif Organs, 29, 841-51, 2006
  17. Ye, H., Das, D. B., Cui, Z., Triffitt, J. T. Modelling nutrient transport in hollow fibre membrane bioreactor for growing dense bone tissue. J Membrane Sci, 272, 169-178, 2006
  18. Xia, Z., Ye, H., Locklin, R. M., Ferguson, D. J., Cui, Z., Triffitt, J. T. Efficient characterization of human cell-bioceramic interactions in vitro and in vivo by using enhanced GFP-labelled mesenchymal stem cells. Biomaterials 26, 5790-5800, 2005
  19. Xia, Z., Ye, H., Choong, C., Ferguson, D. J., Platt, N., Cui, Z. Triffitt, J. T. Macrophagic response to human mesenchymal stem cell and poly(epsilon-caprolactone) implantation in nonobese diabetic/severe combined immunodeficient mice. J Biomed Mater Res 71A, 538-548, 2004. 


Book Chapters

  1. Mouthuy, P, Ye, H. Biomaterials: electrospinning. Comprehensive Biotechnology, 2nd Ed, Vol 5 Murray, M., Ed, 23-36, Elsevier 2011
  2. Zhou, S., Ye, H., Cui, Z. Complexity in modeling of cartilage tissue engineering. Comprehensive Biotechnology, 2nd Ed, Vol 5, Murray, M., Ed, 311-319, Elsevier, 2011
  3. Ye, H., Cui, Z., Ellis, M. J., Chaudhuri, J. B., Macedo, H., Mantalaris, A. Hollow fibre membrane bioreactor technology for tissue engineering and stem cell therapy. Comprehensive Membrane Science and Technology. Vol 3, Drioli, E. , Giorno, L. Eds. Elsevier, 2010
  4. Lim, M., Ye, H., Panoskaltsis, N., Mantalaris, A. Optimal expansion and differentiation of cord blood stem cells using design of experiments. Handbook of Cardiac Stem Cell Therapy. Dimarakis, I., Menasche, P., Habib, N. A., Gordon, M. Y. Eds. 265-282, Imperial College Press, London. 2009


Conference Presentations

  1. George, J.H., Nagel, D., Hill, E.J., El-Sherbini, Y., Ye, H., Cui, Z. A closer look at neurite outgrowth through porous membranes. British Neuroscience Association ‘Festival of Neuroscience’ 2013, 7th April, 2013, London, UK
  2. George, J.H., El-Sherbini Y., Ye, H., Cui, Z. Engineering three-dimensional neural networks using hESCs. Oxford Stem Cell Institute Annual Symposium 2013, 14th March 2013, Oxford, UK
  3. George, J.H., Ye, H., Cui, Z. One network to another - engineering a neural interface through micro-porous membranes. RAE Young Researchers Futures Meeting on Neural Engineering, 19th September, 2012, Warwick University, UK
  4. Wan, X., Ye, H., Cui, Z. Three-dimensional Co-Culture of Vascular Endothelial Cells and Cancer Cells for Drug Testing. NC3Rs/BBSRC tissue engineering symposium, June 12, 2012, London, UK
  5. Wan, X., Cui, Z., Ye, H. Three-dimensional Co-culture Cancer Model with Vascular Endothelial Cell for Anti-cancer Drug Testing. J Tissue Eng Regen M 6 (Suppl. 1) 355, 2012, TERMIS World Congress, September 5-8, 2012, Vienna, AUSTRIA.
  6. Lee, S-Y., El-Sherbini, Y., Ye, H., Seymour, L. Characterisation of human pluripotent stem cell in three-dimensional hydrogel. Submitted to British Society for Gene Therapy Congress 2011, Brighton, 2011
  7. El-Sherbini, Y., Ye, H. Y-27632 ROCK inhibitor improves the efficiency of dissociation of NT2 neurospheres into single neurons. Submitted to Neuroscience 2011, Washington, DC, 2011
  8. Mouthuy, P., Ye, H. Building multilayered cartilage constructs by using electrospinning and cell sheet engineering. Tissue Engineering and Regenerative Medicine International Society-Asia Pacific Chapter Meeting (TERMIS-AP) 2011, Singapore, 2011
  9. Sambu, S., Xu, X., Ye, H., Cui, Z. The cryopreservation of stem cells in 3D alginate constructs. BioProcess UK Annual Symposium, Manchester, 2010
  10. Mouthuy, P., Ye, H., Oommen, G., Cui, Z. Physico-chemical characterization of functional electrospun scaffolds for bone and cartilage tissue engineering. Tissue Engineering and Regenerative Medicine International Society-EU Chapter Meeting (TERMIS-EU) 2010, Galway, 2010
  11. Ye, H., Tissue engineering and stem cell bioprocessing. 8th International Conference on Cell and Stem Cell Engineering, Dublin, 2010
  12. Mouthuy, P., Cui, Z., Ye, H. Towards Engineering of Osteochondral Grafts. Bioengineering 09, Oxford, UK, 2009
  13. Lim, M., Ye, H., Panoskaltsis, N., Mantalaris, A. In-vitro erythropoiesis of cord blood haematopoietic stem cells using design of experiments. ISEH Annual Meeting, Hamburg, Germany, 2007
  14. Lim, M., Ye, H., Panoskaltsis, N., Yue, X., Drakakis, E.M., Radomska, A., Cass, A.E.G., Mantalaris A. Generating spatial and temporal profiles for haematopoietic stem cell cultures using DOE and online monitoring: towards intelligent bioprocessing. TERMIS AP, Tokyo, Japan, 2007
  15. Lim, M., Ye, H., Panoskaltsis, N., Yue, X., Drakakis, E.M., Radomska, A., Cass, A.E.G., Mantalaris A. Intelligent stem cell bioprocessing for cord blood haematopoietic stem cell cultures. ICCMB conference, Singapore, 2007
  16. Yue, X., Drakakis, E., Ye, H., Lim, M., Mantalaris, A., Panoskaltsis, N., Radomska, A., Toumazou, C., Cass, A. An on-line, multi-parametric, multi-channel physicochemical monitoring platform for stem cell culture bioprocessing. IEEE International Symposium on Circuits and Systems (ISCAS): 1215-1218, New Orleans, USA, 2007  (Live Demo Award) 
  17. Yue, X., Drakakis, E., Toumazou, C., Ye, H., Mantalaris, A., Radomska, A., Cass, A.  8×16 Channel physiological monitoring platform of stem cell culture systems. IEEE Biomedical Circuits and Systems Conference (BIOCAS), London, 2006
  18. Ye, H., Lim, M., Yue, X., Radomska, A., Cass, A., Drakakis, E., Panoskaltsis, N., Mantalaris, A., Toumazou, C. Ex vivo expansion and differentiation of haematopoietic stem cells (HSCs) using on-line monitoring and design of experiments (DOE): case study of erythropoiesis of cord blood stem cells. Oral presentation at AIChE Annual Conference, San Francisco, USA, 2006
  19. Lim, M., Ye, H., Panoskaltsis, N., Mantalaris, A. Full Process Characterization of Haematopoietic Stem Cell Cultures Using Design of Experiments to Study Individualistic and Interactive Effects of Culture Parameters. Oral presentation at AIChE Annual Conference, San Francisco, USA, 2006
  20. Das, D. B., Ye, H., Abdullah, N. S., Cui, Z. F. Modelling nutrient transport in hollow fibre membrane bioreactors for bone tissue growth. Oral presentation at 4th Annual Meeting of the European Tissue Engineering Society, Munich, Germany, 2005
  21. Ye, H., Das, D. B., Cui, Z. F. Modelling Hollow Fibre Membrane Bioreactor for Growing Bone Tissues: Effects of Process Parameters. Oral presentation at Engineeing with Membranes: Medical and Biological Applications, Camogli, Italy, 2005
  22. Ye, H., Xia, Z., Ferguson D. J. P., Triffitt, J. T., Cui, Z. Hollow-fibre membrane bioreactors for 3D tissue generation. Cytotherapy 6[3], 276, 2004. Oral presentation at Strategies in Tissue Engineering, Würzburg, Germany, 2004
  23. Xia, Z., Ye, H., Ferguson D. J. P., Cui, Z., Triffitt, J. T. Transfection efficiency and fate of eGFP-labelled human mesenchymal stem cells incorporating ceramics in NOD/SCID mice. Cytotherapy 6[3], 264, 2004. Oral presentation at Strategies in Tissue Engineering, Würzburg, Germany, 2004
  24. Xia, Z., Choong, C., Ye, H., Platt, N., Cui, Z., Triffitt, J. T. Macrophagic response to human osteogenic stem cells in SCID/NOD mice. Tissue Engineering 8[6], 1250. 2002. Poster presentation at the 5th Annual Meeting of the Tissue Engineering Society International, Kobe, Japan, 2002
  25. Ye, H., Xia, Z., Ferguson D. J. P., Cui, Z., Triffitt, J. T. Evaluation of biocompatibility of scaffolds for orthopaedic tissue engineering using enhanced green fluorescent protein (EGFP)-labeled human bone marrow fibroblastic stem cells. Poster presentation at the Third Smith & Nephew Symposium-Translating Tissue Engineering into Products, Atlanta, USA, 2002
  26. Xia, Z., Ye, H., Ferguson D., Cui, Z., Triffitt, J. T. Interactions of calcium phosphate ceramics with green fluorescent protein (GFP)-labelled human bone marrow osteogenic stem cells. Oral presentation at the 3rd Annual Symposium of the Tissue and Cell Engineering Society, Stoke-on-Trent, UK, 2001