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Julian F Dye


Current Position                  Departmental Lecturer

Contact Information            CRMI group, IBME,
                                           Dept Engineering Science,
                                           Old Road Campus Research Building,
                                           University of Oxford
                                           Oxford OX3 7DQ

                                           Tel: 01865617915

Research Interests

Bio-intelligent scaffolds / tissue reconstruction / angiogenesis




MA (Hons) Biochem (Oxon), PhD Physiol (Lon)


Work Experience                                             

Julian graduated in Biochemistry at St Anne’s College, Oxford and joined the Surgical Unit, St Mary’s Hospital Medical School, Paddington as a research biochemist MLSO in 1984. He then moved to Dept Anatomy & Cell Biology, Imperial College School of Medicine to do his PhD in endothelial cell biology, and followed this with a joint post-doctoral project with St Mary's Hospital Medical School, Manchester, working on pre-eclampsia. He then moved to The RAFT Institute, finally being Director of Research. Here he established a research programme to develop a new approach to skin reconstruction, inventing an artificial skin material called ‘Smart Matrix’, a pro-angiogenic synthetic dermal replacement. He developed this into a clinical product and translated the manufacture to clinical clean rooms, for clinical trial in reconstruction of surgical excision wounds. This involved setting up a start-up company for which he was CSA during the incubating stage, from 2011-13. The product is now in commercialisation. From this he moved into academia with a Lecturer (fixed term post) at the Open University, and joined IBME in 2016. He now leads a group developing Bio-Intelligent Biomaterial Scaffolds and clinically relevant and cost-economic biomaterial manufacture processes.



  • Dye, JF (Priority date 3/5/2012) Extracellular Matrix - Synthetic Skin Scaffold PCT/GB2013/051158
  • Dye, JF & Reece, J. (Priority date 16/11/2011) Synthesis apparatus for artificial skin. GB1114082.9. (Lapsed for commercial reasons.)
  • Dye JF (Priority date 16/6/2006) Extracellular Matrix Composition. WO 2007/144644 A2 (Granted EU/US)
    • EU Patent granted 25/9/2012 Pat No. EP2035047
    • US Patent granted 15/9/2012 Pat No. 8,273,372


Recent Publications

Journal Papers

Sharma V, Blackwood KA, Haddow D, Hook L, Mason C, Dye JF, Gareta-Garcia E. (2015) Method for estimating protein binding capacity of polymeric systems. Biochemie Open 1 p40-50.

Sharma V, N, Dye, JF, Mason, C, Gareta-Garcia E. (2015). Albumin removal from human fibrinogen preparations for manufacturing human fibrin-based biomaterials. Biochemie Open 1 [6/6/2015] p6-10.

Elizabeth Ann Wahl, Fernando Fierro, Thomas R Peavy, Ursula Hopfner, Julian F Dye, Hans-Günther Machens, José T. Egaña, Thilo L. Schenck (2014) Evaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Increase Angiogenesis In Vivo.BioMed Research International. 108571 (9/4/15).

Gareta-Garcia, E, Ravindran, N & Dye, J F. (2014) Apoptotic primary normal human dermal fibroblasts for in vitro models of fibrosis. Analytical Biochemistry. doi:

Tanja Macheiner, Anna Kuess, Julian Dye, Amulya K Saxena. (2014) A novel method for isolation of epithelial cells from ovine esophagus for tissue engineering. Bio-medical materials and engineering. 24(2):1457-1468.

Gareta-Garcia, E, Ravindran, N, Sharma, V Samizadeh, S & Dye, J F. (2013) A Novel Multiparameter In Vitro Model of Three-Dimensional Cell Ingress Into Scaffolds for Dermal Reconstruction to Predict In Vivo Outcome. BioResearch Open Access 2 (6) 412-420.

Dye, JF (2012) Guest Editorial. A synthetic scaffold to treat full thickness wounds. Wounds International 6 (2), 6-7

Caiado, F Carvalho, Fernanda Silva, Catarina Castro, Nuno Clode, J. F. Dye & Sergio Dias (2011). Fibrin E modulates endothelial progenitors adhesion, differentiation and angiogenic growth factor production and promotes wound healing. Biomaterials 32 (29) 7096-105.

Egaña JT, Danner S, Kremer M, Rapoport DH,  Dye JF, Lavandero S, Kruse C, Machens HG. (2009) Glandular-derived stem cells improve vascularisation in scaffold-mediated dermal regeneration Biomaterials 30(30): 5918-26.

Edwards FC., Taheri A., Dann SC. & Dye JF. (2011) Characterisation of cytolytic neutrophil activation in vitro by amorphous hydrated calcium phosphate as a model of biomaterial inflammation. J Biomed Mat Res pt A, 96A (3) 552-565.

Bitto, A, Galeano, M, Squadrito, F, Minutoli, L, Polito, F., Dye, JF, Clayton, EA, Calo, M., Ventuti, F, Altavilla, D. (2008) Polydeoxyribonucleotide (PDRN) improves angiogenesis and wound healing in experimental thermal injury. Critical Care Medicine 2008. 36(5): p. 1594-602.

Baldwin, C., Potter, M., Clayton, E., Irvine, I. & Dye, JF. (2009) Vacuum assisted closure accelerates the integration of Integra - a suggested mechanism of action. Ann Plast Surg. Jan;62(1):92-6.

Potter, M., Banwell, P., Baldwin, C., Clayton, L., Irvine, L, Linge, C., Grobbelaar, A.O, Sanders, R & Dye, JF. (2008). In vitro optimisation of Topical Negative Pressure regimes for angiogenesis into Synthetic Dermal Replacements. Burns. 34(2): 164-174.

Potter, M., Linge, C., Cussons, P., Dye, JF., & Sanders, R. (2006) An investigation to optimise angiogenesis within potential dermal replacements. Plas. Recon. Surg. Vol 117 (6), p1876-1885.

Dye, JF., Barnett, M., Linge, C. and Sanders, R. (2004) The angiogenic sprouting response to collagen requires src family kinase activity. Proceedings of the 23rd European Conference on Microcirculation, ed.  Martins e Silva J., Saldanha C., Oliveira V., Prie A., Shore A. Medimond. Bologna. p87-93.

Potter, M, Linge, C, Dye, JF, and Sanders, R. (2004) Fibrin is a potent stimulus of endothelial cell migration. Proceedings of the 23rd European Conference on Microcirculation, ed.  Martins e Silva J., Saldanha C., Oliveira V., Prie A., Shore A., Medimond. Bologna. P131-135.

Dye, J. F., Laurence, L., L. Leach, L., Linge, C., Firth.J.A. & P. Clark. (2004) Distinct patterns of in vitro angiogenic behaviour of human microvascular endothelial cells is determined by extracellular matrices. Endothelium 11 (3/4) p151-167.

Dye, J. F., Vause, S., Johnston, T, Clark, P., Firth, JA., D’Souza, SWS., Sibley, CP. and Glazier, JD. (2004) Characterisation of cationic amino acid transporters and expression of nitric oxide synthase in human placental microvascular endothelial cells. FASEB J. Rapid communication online Nov 2003

Leach, L., MO. Babawale, MJ. Lammiman, JF. Dye, P. Clark and JA. Firth (2002) Endothelial phenotype of the materno-fetal barrier. J Anat 200 (5) p531.

Dye, J. F., Clark, P., Leach, L., and Firth, J. A. (2001) Cyclic AMP and acidic fibroblast growth factor have opposing effects on tight and adherens junctions in microvascular endothelial cells in vitro. Microvascular Research. 62 (2), 94-113.

Dye, J. F., Jablenska, R., Donnelley, J.L., Lawrence, L., Leach, L., Clark, P., and Firth, J. A. (2001) Phenotype of the endothelium in the human term placenta. Placenta. 22, 32-43.

Book Chapters                 

Potter, M, Baldwin, CJ Edwards, FC, Dann, SC, Zarb Adami, R & Dye, JF. (2016) From Secondary Intent to Accelerated Regenerative Healing: Emergence of the Biointelligent Scaffold Therapeutic Strategy for chronic wounds. In (Ed Agren, M.) Advances in Wound Healing Technologies. Woodhead Press, Elsevier Cambridge.


Conference Proceedings

European society for Biomaterials, Kackow 30 Aug-3rd Sept 2015.

Dye JF, Scionti G, Wahl EA, Egana, T & Khoury, K. Vasculogenesis and Accelerated Healing through the Emergent Design of an Hierarchically Structured Scaffold.

Bioengineering 2013, Glasgow 16-17th Sep 2013.

A Wilson, J F Dye, P E Butler, A Seifalian. Adipose-derived stem cells: isolation within the intraoperative timeframe and characterisation.

E García-Gareta, N Ravindran, V Sharma, S Samizadeh, JF Dye. A Novel In Vitro Model Of 3d Cell Ingress Into Scaffolds For Dermal Reconstruction To Predict In Vivo Outcome.

ETRS Reims 2013

S Samizadeh, E. G Garcia, L. M Irvine, J. F Dye. Single enzyme isolation and characterization of human placenta mesenchymal stem cells.

S Samizadeh, E. G Garcia, L. M Irvine, J. F Dye. Differential regulation of cytokine and growth factor profiles involved in cell integration of collagen and fibrin based scaffolds in vitro.

Tissue & Cell Engineering Society (TCES) Cardiff July 2013

Gareta-Garcia, E, Ravindran, N, Sharma, V Samizadeh, S & Dye, JF. An In Vitro Model of 3D cell ingress into Scaffolds For Dermal Reconstruction To Predict In Vivo Outcome.

Sorousheh Samizadeh, Elena Garcia-Gareta, Mr Laurie M Irvine, Julian F Dye. Single Enzyme Isolation And Characterization Of Human Placenta Mesenchymal Stem Cells.

N Ragunathan, V Sharma, N Ravindran, E García-Gareta & JF Dye. Comparison of the mechanical properties of Smart Matrix™, Integra® and Matriderm® dermal scaffolds.

V Sharma, KA Blackwood, D Haddow & JF Dye. Protein binding functionalisation of plasma-derivatized silicone surfaces.

The International Society for Burn Injuries (IBSI) Annual Conference, Edinburgh (10-13/9/12)

Zarb Adami R, Sharma V, Ravindran N, RagunathanN, Patel N, Garcia E & Dye JF. A novel approach to create a compromised pre-clinical full thickness wound model using a partially excised burn.

J Dye (2013) From secondary intent to accelerated reconstruction - the prospect of dermal scaffolds. EPA492 EWMA Copenhagen 23-25th May 2013.

Dye, JF & Lindsay, E (2012) Taking Wound Healing to the grass roots: a collaboration of research and patient care. EWMA Journal 12 (2) 172.

K. A. Blackwood, A Taheri & JF Dye. (2011) Optimising the production criteria of Smart MatrixTM fibrin based scaffold. Eur Cells Mat 22 (suppl 2) 35.

Raina Zarb Adami, Amir Taheri, Nimesha Patel, Keith Blackwood & Julian F Dye. (2010) Healing outcome of dermal reconstruction using the Smart MatrixTM Fibrin/Alginate composite scaffold: in vitro and pre clinical evidence.


Julian F Dye, Sophie C Dann, Christopher Baldwin (2010) Intersecting design criteria for development of a Smart MatrixTM Synthetic Dermal Replacement. TERMIS EU Galway 2010 Abstract 356 (

Julian F Dye, Sophie C Dann, Christopher Baldwin (2010) Clinical drivers for integrated solutions to synthetic dermal reconstruction. TERMIS EU Galway 2010 Abstract 229 (

Amir Taheri, Nimesha Patel, Sophie C Dann & Julian F Dye (2010) Vasculogenesis in rapid integration of a synthetic dermal scaffold: efficacy for single-stage full thickness surgical reconstruction. TERMIS EU Galway 2010 Abstract 339 (


Conference Presentations

Omics International Conference & Expo on Biomaterials, London 14-15 Mar 2016

Dye JF. Vasculogenesis and Accelerated Healing through the Emergent Design of

an Hierarchically Structured Scaffold. Journal of Biotechnology and Biomaterials


Conference of Cell & Biological Therapies for Trauma & Orthopaedics (Santiago, 27-28/11/14).

Bio-intelligent Scaffolds for accelerated healing. (Opening session keynote lecture)


Wound Technology Forum (Journal of Wound Care), Manchester 14th Mar 2014.

JF Dye & E Lindsay. From Secondary Intent to Accelerated Regenerative Healing: Emergence of the Bio-Intelligent Scaffold Therapeutic Strategy.(Oral presentation)


1st German-Chilean conference in regenerative biology and medicine, Catholic University, Santiago 1-4th Mar 2013.

JF Dye. The Smart Matrix™ Synthetic Dermal Scaffold for skin reconstruction. (Opening keynote lecture)


JF Dye. The pathway for clinical translation of Smart Matrix(TM) as an example Tissue Scaffold product. (Oral presentation)


Lindsay Leg Club Foundation AGM, March 2011

Development of the pro-angiogenic Smart Matrix Synthetic Dermal Replacement for skin reconstruction. (Invited talk).


3rd International Workshop on Wound Technology. Paris, 16-17th Jan 2011.

Julian F Dye. Long-term Healing Outcome of Dermal Reconstruction Using the ‘Smart Matrix’ Fibrin/Alginate Composite Scaffold: In Vitro and Pre-Clinical Evidence. (Oral presentation)


Funding                               Concorcio Regenero

Collaborators                    UANDES


Interfacial Chemistry and Applications, for Chemical Engineering, Tissue Engineering for Biomedical Engineering, and 3rd & 4th year project supervisions.