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Fabio Bianchi

Current Position                     D.Phil. Student


College                                  Balliol College


Supervisor(s)                          Prof Hua (Cathy) Ye and Dr Mark Thompson (Mechanobiology group)


Contact Information                Institute of Biomedical Engineering
                                               Department of Engineering Science
                                               Oxford, UK
 
                                                Tel: +44 1865 617654
                                                E-mail:  

Research Interests

Peripheral nervous system damage and regeneration, neural stem cell therapy for peripheral nerve damage, in vitro models of mechanical damage to neurons

 

Background

Education

M.Eng. Mechatronics – King’s College London (First class)

M.Sc. Biomedical Engineering – Balliol College, University of Oxford (Distinction)

 

Work Experience

Second and third year tutorial teaching (Biomechanics and Structures, materials and dynamics) – department of Engineering Science, Oxford

Second year lab demonstration (Tissue Engineering) – department of Engineering Science, Oxford

 

Awards and Scholarships

EPSRC DTP (Doctoral Training Partnership) awarded for 3.5 years

 

Publications

Journal Papers

Wei, Wei-Chun, Fabio Bianchi, Yang-Kao Wang, Ming-Jer Tang, Hua Ye, and Maike D. Glitsch. "Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)." Current Biology (2018). https://doi.org/10.1016/j.cub.2018.10.046

3D finite element formulation for mechanical-electrophysiological coupling in axonopathy. Man Ting Kwonga, Fabio Bianchi, Majid Malboubi, Julián Andrés García-Grajales, Lina Homsi, Mark Thompson, Hua Ye, Ludovic Noels, Antoine Jérusalem. Science Direct. https://doi.org/10.1016/j.cma.2018.09.006

Evidences of the Effect of GO and rGO in PCL Membranes on the Differentiation and Maturation of Human Neural Progenitor Cells. Sandra Sánchez‐González, Nazely Diban, Fabio Bianchi, Hua Ye,  Ane Urtiaga. Macromolecular Bioscience. https://doi.org/10.1002/mabi.201800195

Fabio Bianchi, Majid Malboubi, Julian H. George, Antoine Jerusalem, Mark S. Thompson, Hua Ye. Rapid and efficient differentiation of functional motor neurons from human iPSC for neural injury modelling.Stem Cell Research. In Press

Fabio Bianchi, Shichen Zhu, Xingyue Maria Wang, Zhe Lu, Rongrong Zou, Jiandong Li, Jianming. Probing multi-scale mechanics of peripheral nerve collagen and myelin by x-ray diffraction. Journal Mechanical Behaviour of Biomedical Materials. In Press

Fabio Bianchi, Ruby Sedgwick, Hua Ye, Mark S. Thompson. Strain partitioning between nerves and axons: estimating axonal strain using sodium channel staining in intact peripheral nerves, Journal of Neuroscience Methods, (2018). ISSN 0165-0270, https://doi.org/10.1016/j.jneumeth.2018.08.003

Bianchi, F., Hofmann, F., Smith, A.J., Thompson, M.S., Probing multi-scale mechanical damage in connective tissues using x-ray diffraction, Acta Biomaterialia (2016), doi: http://dx.doi.org/10.1016/j.actbio.2016.08.027

Soliman, E., Bianchi, F., Sleigh, J.N., George, J.H., Cader, M.Z., Cui, Z. and Ye, H., (2017). Engineered method for directional growth of muscle sheets on electrospun fibers. Journal of Biomedical Materials Research Part A. 10.1002/jbm.a.36312

Soliman, E., Bianchi, F., Sleigh, J.N., George, J.H., Cader, M.Z., Cui, Z. and Ye, H., (2018). Aligned electrospun fibers for neural patterning. Biotechnology Letters, pp.1-7.

Bianchi, F., Hofmann, F., Smith, A. J., Ye, H., & Thompson, M. S. (2018). Probing multi-scale mechanics of peripheral nerve collagen and myelin by x-ray diffraction. Journal of the Mechanical Behavior of Biomedical Materials.

 

Conference Proceedings

Adaptive internal impedance control for stable walking on uncertain visco-elastic terrain Bianchi, . F., Bartoli, G., Shoar, K., Fernandez, M. R. A., Pereno, V., Zirjakova, J., Jiang, A. & Nanayakkara, T. 7 Oct 20122012 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS). N/A ed. Piscataway: IEEE, Vol. N/A,p. 2465 – 2470

Stable Walking on Variable Visco-Elastic Terrains Using Meta-Parameters for Passive State Migration Pereno, V., Shoar, K., Bartoli, G., Bianchi, . F. & Nanayakkara, T. 4 Nov 2013 2013 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS). IEEE, p. 3127-3131

 

Conference Presentations

Probing multi-scale damage effects and mechanical properties of connective tissues by x-ray diffraction (Size-Strain VII, Oxford, September 2015)

Engineered Methods for Directional Growth of Innervated Muscle Sheets on Electrospun Fibres (Oxford Interdisciplinary Bioscience Networking Event, March 2015)

Collagen to Axons – Mechanical effects on peripheral nerves (MEIBioeng 2016, Oxford, UK, Sept 2016)

Probing multi-scale damage effects and mechanical properties of connective tissues by x-ray diffraction (European Society of Biomechanics, Lyon, July 2016)

Tensile loading with in situ x-ray diffraction suggests high myelin sheath stiffness in peripheral nerve (8th World Congress of Biomechanics, Dublin, July 2018)

 

Poster Presentations

Membrane cholesterol addition reduces functionality loss in stretch-injured neurons (8th World Congress of Biomechanics, Dublin, July 2018)