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Hui Wang

Current Position            Senior research fellow

Contact Information       Department of Zoology
                                      The Tinbergen Building
                                      South Parks Rd
                                      Oxford OX1 3PS

                                      07704529932
                                      

                                      http://www.zoo.ox.ac.uk/people/view/wang_h.htm

 

Research Interests

Next Generation Sequencing for Stem Cells: To use the next generation sequencing technology to characterise stem cells and products.

 

Collaborators

The Beijing Genomics Institute (BGI), Shenzhen, China

 

Background

Education
March 1995         D.Phil, Virology, St Cross College/Department of Biochemistry, University
                          of Oxford, Oxford, UK.
June 1990            M.Sc, Plant Physiology, College of Biological Sciences, Beijing
                           Agricultural University, Beijing, China.
July 1987             B.Sc, Agriculture, Department of Agronomy, Beijing Agricultural
                           University, Beijing, China.

Work Experience
2014-present     Senior Research Fellow on Genomics, Department of Zoology, University of
                        Oxford, Oxford OX1 3PS, UK
2002-2014         Principal Scientific Officer (NERC Band 4) and Group Leader of Plant
                        Virus, NERC/CEH-Oxford, then NERC/CEH-Wallingford since 2010,
                        OX10 8BB, UK
1999-2001         Senior Scientific Officer (NERC Band 5), NERC/CEH-Oxford, Oxford
                        OX1 3SR, UK
1995-1999         Postdoctoral Higher Scientific Officer (NERC Band 6), NERC/Institute of
                        Virology and Environmental Microbiology (IVEM), Oxford OX1 3SR, UK
1991-1995         Research Student for D. Phil., Dept Biochemistry, University of Oxford, UK
1990-1991         Research Assistant, Institute of Genetics, Chinese Academy of Science,
                        Beijing, China

 

Awards and Scholarships

1997          H. Wang. Cell-based assay for HCV ns3 protease activity. 4th International
                 Meeting on Hepatitis C Virus and Related Viruses (Molecular Virology and
                 Pathogenesis), Kyoto, Janpan, 1997, Young Scientist Award.
1992-94      H. Wang (Student) and P. A. Nuttall (Supervisor). Overseas Research Student
                 (ORS) Award, British Universities Committee.
1991-95      H. Wang (Student) and P. A. Nuttall (Supervisor). Mallinckrodt Veterinary Ltd.
                  Scholarship (research studentship for D.Phil.). St. Cross College, University of
                  Oxford.

 

Patents

Inventors: NUTTALL, P.A., and WANG, H. (1995)

Owner: Mallinckrodt Veterinary Ltd.

Title:  Parasite Immunoglobulin Binding Proteins, and their use as vaccines

File No.:  27.61023/GB                 WP Ref. No.:  61023.575

Int. Pub. No.: WO/95/27056

 

Inventors: WANG, H., and NUTTALL, P.A. (2006)

Owner: Natural Environmental Research Council, UK

Patent agent: Mewburn Ellis, London

Title: Compositions comprising IGBPMA and uses thereof

International Patent Application No: PCT/GB2006/003986

Int. Pub. No.: WO/2007/051975

 

Inventors: WANG, Hui, HE Yi, HUANG Wei, ZHANG Dayi (2010)

Owner: Natural Environmental Research Council, UK

Patent agent: Barker Brettell LLP, Birmingham

Title: Biosensor and uses thereof

International Patent Application No: PCT/GB2011/052228

Int. Pub. No.: WO/2012/066321

 

Inventors: WANG, H., and NUTTALL, P.A. (2012)

Owner: Natural Environmental Research Council, UK

Patent agent: JA Kemp, London

Title: IgA-binding protein

British Patent Application No. 1203337.9

 

Publications

Journal Papers

Jinmin Ma, Denise Pallett, Hui Jiang, Yong Hou, Hui Wang* (2015). Mutational Bias of Turnip Yellow Mosaic Virus in the Context of Host Anti-viral Gene Silencing. Virology 486: 2-6, doi:10.1016/j.virol.2015.08.024.

Jin Luo, Guang-Yuan Liu, Ze Chen, Qiao-Yun Ren, Hong Yin, Jian-Xun Luo, Hui Wang (2015). Identification and characterization of microRNAs by deep-sequencing in Hyalomma anatolicum anatolicum (Acari: Ixodidae) ticks. Gene 564(2):125-33, doi: 10.1016/j.gene.2015.01.019.

Shan Gao*, Chen Yang*, Shan Jiang, Xiaoning Xu, Xin Lu, You-Wen He, Annie Cheung, Hui Wang* (2014). Applications of RNA interference high-throughput screening technology in cancer biology and virology. Protein and Cell 5(11):805-15, DOI 10.1007/s13238-014-0076-6.

Yajing Wang, Hui Wang*, Kunhan Xu, Peixiang Ni, Huan Zhang, Jinmin Ma, Huanming Yang, Feng Xu* (2014). A Survey of Overlooked Viral Infections in Biological Experiment Systems. PLoS ONE 9(8): e105348. doi:10.1371/journal.pone.0105348

Shelagh K. Malham, Paulina Rajko-Nenow, Eleanor Howlett, Karen E. Tuson, Tracy L. Perkins, Denise W. Pallett, Hui Wang, Colin F. Jago, Davey L. Jones and James E. McDonald (2014). The interaction of human microbial pathogens, particulate material and nutrients in estuarine environments and their impacts on water quality and shellfish waters. Environmental Science: Processes & Impacts 16(9):2145-55. DOI: 10.1039/C4EM00031E

Shelley Cook, Betty Y.-W. Chung, David Bass, Gregory Moureau, Shouya Tang, Erica McAlister, C. Lorna Culverwell, Edvard Glucksman, Hui Wang, T. David K. Brown, Ernest A. Gould, Ralph E. Harbach, Xavier de Lamballerie, Andrew E. Firth (2013). Novel virus discovery and genome reconstruction from field RNA samples reveals highly divergent viruses in dipteran hosts. PLoS ONE 8(11): e80720. doi:10.1371/journal.pone.0080720

Hui Wang*, Jiazheng Xie, Tim G. Shreeve, Jinmin Ma, Denise W. Pallett, Linda A. King, Robert D. Possee (2013). Sequence recombination and conservation of Varroa destructor virus-1 and Deformed wing virus in field collected honey bees (Apis mellifera). PLoS ONE 8(9): e74508. doi:10.1371/journal.pone.0074508

Chunjie Fan, Jinmin Ma, Qirong Guo, Xiaotie Li, Hui Wang*, Mengzhu Lu* (2013). Selection of Reference Genes for Quantitative Real-Time PCR in Bamboo (Phyllostachys edulis). PLoS One 8(2): e56573. doi:10.1371/journal.pone.0056573

Jack A. Gilbert, Yiming Bao, Hui Wang, Susanna-Assunta Sansone, Scott C. Edmunds, Norman Morrison, Folker Meyer, Lynn M. Schriml, Neil Davies, Peter Sterk, Jared Wilkening, George M. Garrity, Dawn Field, Robert Robbins, Daniel P. Smith, Ilene Mizrachi, Corrie Moreau (2012). Report of the 13th Genomic Standards Consortium Meeting, Shenzhen, China, March 4–7, 2012. Standards in Genomic Sciences 6:276-286.

Dayi Zhang, Yun Zhao, Yi He, Yun Wang, Yiyu Zhao, Yi Zheng, Xia Wei, Litong Zhang, Yuzhen Li, Tao Jin, Lin Wu, Hui Wang, Paul A. Davison, Junguang Xu, and Wei E. Huang (2012). Characterization and modelling of transcriptional cross-regulation in Acinetobacter baylyi ADP1. ACS Synthetic Biology 1: 274-283.

Dayi Zhang, Yi He, Yun Wang, Hui Wang*, Lin Wu, Eric Aries and Wei E. Huang* (2012). Whole-cell bacterial bioreporter for actively searching and sensing of alkanes and oil spills. Microbial Biotechnology 5: 87-91.

Zhancheng Tian, Guangyuan Liu, Liyan Zhang, Hong Yin, Hui Wang, Junren Xie, Ping Zhang, Jin Luo (2011). Identification of the heat shock protein 70 (HLHsp70) in Haemaphysalis longicornis. Veterinary Parasitology 181: 282-290.

Dayi Zhang, Rawil F. Fakhrullin, Mustafa Özmen, Hui Wang, Jian Wang, Vesselin N. Paunov, Guanghe Li, and Wei E. Huang (2011). Functionalisation of whole cell bacterial reporters with magnetic nanoparticles. Microbial Biotechnology 4: 89-97.

Thien Ho, Liang Wang, Linfeng Huang, Zhigang Li, Denise W. Pallett, Tamas Dalmay, Kazusato Ohshima, John A. Walsh, Hui Wang* (2010). Nucleotide bias of DCL and AGO in plant anti-virus gene silencing. Protein and Cell 1: 847-858.

Denise W. Pallett, Thien Ho, Ian Cooper, and Hui Wang* (2010). Detection of Cereal yellow dwarf virus using small interfering RNAs and enhanced infection rate with Cocksfoot streak virus in wild cocksfoot grass (Dactylis glomerata). Journal of Virological Methods 168:223-227.

Chao Li, Hui Wang*, Lin Zhou, Yongjun Zhang, Fuping Song, Jie Zhang* (2009). Quantitative measurement of pH influence on SalR regulated gene expression in Acinetobacter baylyi ADP1. Journal of Microbiological Methods 79: 8-12.

E. Soh, D. W. Pallett, K. Bodey, L. C. K. Lau, H. Whitworth, A. Page, M. Edwards, P. H. Howarth, J. I. Cooper, H. Wang, A. F. Walls (2009). Virus infection of grass can alter the allergenic potency of pollen. Clinical & Experimental Allergy 39: 1939.

Denise W. Pallett, Emily Soh, Mary-Lou Edwards, Kathleen Bodey, Laurie C.K. Lau, J. Ian Cooper, Peter H. Howarth, Andrew F. Walls*, Hui Wang* (2009). Proof of concept pilot study: prevalence of grass virus infection and the potential for effects on the allergenic potency of pollen. Environmental Health 8 (Suppl I):S10, doi:10.1186/1476-069X-8-S1-S10 (Open Access, http://www.ehjournal.net/content/8/S1/S10)

Thien Ho, Rachel L Rusholme Pilcher, Mary-Lou Edwards, Ian Cooper, Tamas Dalmay, and Hui Wang* (2008). Evidence for GC preference by monocot Dicer-like proteins. Biochemical and Biophysical Research Communications 368: 433-437.

D. W. Pallett, J. I. Cooper, H. Wang, J. Reeves, Z. Luo, R. Machado, C. Obermeier, J. A. Walsh and M. J. Kearsey (2008). Variation in the pathogenicity of two Turnip Mosaic Virus isolates in wild UK Brassica rapa provenances. Plant Pathology 57: 401-407

Thien X. Ho, Rachel Rusholme, Tamas Dalmay, and Hui Wang* (2008). Cloning of short interfering RNA from virus-infected plants. Plant Virology Protocols II. (ed. G. Foster et al.), Methods in Molecular BiologyTM 451: 229-242. The Humana Press Inc.

Thien Ho, Hui Wang*, Denise Pallett, and Tamas Dalmay (2007). Evidence for targeting common siRNA hotspots and GC preference by plant Dicer-like proteins. FEBS Letter 581: 3269-3274.

Thien Ho, Denise Pallett, Rachel Rusholme, Tamas Dalmay, Hui Wang* (2006). A simplified method for cloning of short interfering RNA from Brassica juncea infected with Turnip mosaic potyvirus and Turnip crinkle carmovirus. Journal of Virological Methods 136:217-223.

Wei E. Huang, Linfeng Huang, Gail M. Preston, Martin Naylor, John P. Carr, Yanhong Li, Andrew C. Singer, Andrew S. Whiteley, and Hui Wang* (2006). Quantitative in situ assay of salicylic acid in tobacco leaves using a genetically modified biosensor strain of Acinetobacter sp. ADP1. The Plant Journal 46: 1073-1083.

H. Wang*, L.F. Huang, and I.J. Cooper (2006). Analyses on mutation patterns, detection of population bottlenecks, and suggestion of deleterious-compensatory evolution among the Potyvirus. Archives of Virology 151: 1625-1633.

D W PALLETT, L HUANG, J I COOPER and H WANG (2006). Within-population variation in hybridisation and transgene transfer between wild Brassica rapa and Brassica napus in the UK. Annals of Applied Biology 148: 147-155.

H. Zhou, H. Wang*, LF. Huang, M. Naylor, and P. Clifford (2005). Heterogeneity in codon usages of Sobemovirus genes. Archives of Virology 150:1591 – 1605.

L.F. Huang, M. Naylor, D.W. Pallett, J. Reeves, J.I. Cooper, and H. Wang* (2005). The complete genome sequence, organization and affinities of Carrot red leaf virus. Archives of Virology 150: 1845-1855

M. Naylor, J. Reeves, J.I. Cooper, M-L Edwards, and H. Wang (2005). Construction and properties of a gene-silencing vector based on Poplar mosaic virus (genus Carlavirus). Jounral of Virological Methods 124: 27-36

Wei E. Huang, Hui Wang, Hongjun Zheng, Linfeng Huang, Andrew C. Singer, Ian Thompson, and Andrew S. Whiteley (2005). Chromosomally located gene fusions constructed in Acinetobacter sp. ADP1 for the environmental detection of salicylate. Environmental Microbiology 7: 1339-1348

XU, Y., GAO, S. S., COLE, D. K., ZHU, J., WANG, H., GAO, G. F., AND RAO, Z. (2004). Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses. Biochemical and Biophysical Research Communication 315:664-670.

PALLETT, D.W., THURSTON, M.I., EDWARDS, M.-L., NAYLOR M., WANG, H., ALEXANDER, M., GRAY, A.J., MITCHELL, E., RAYBOULD, A.F., WALSH, J.A., AND COOPER, J.I. (2004). A tired approach to risk assessment of virus resistance traits based on studies with wild brassicas in England. Conference Proceeding, Assessment of the Impacts of Genetically Modified Plants (AIGM) 2003 Amsterdam, Chapter 23. pp309-322. In: den Nijs,  H.C.M., Bartsch, D. and Sweet,J. (Eds) Introgression from Genetically Modified Plants into Wild Relatives , CABI Publishing. (April, 2004).

WANG, H.*, HAILS, R. S., CUI, W. W., AND NUTTALL, P. A. (2001). Feeding aggregation of the tick Rhipicephalus appendiculatus (Ixodidae): benefits and costs in the contest with host responses. Parasitology 123:447-453.

WANG, H.*, KAUFMAN, W. R., CUI, W. W., AND NUTTALL, P. A. (2001). Molecular individuality and host adaptation in changed environments of the tick Rhipicephalus appendiculatus (Ixodidae). Medical and Veterinary Entomology 15: 1-9.

WANG, H.*, AND NUTTALL, P.A. (2001). Intra-stadial tick-borne thogoto virus (Orthomyxoviridae) transmission: accelerated arbovirus transmission triggered by host death. Parasitology 122:439-446.

WANG, H., AND NUTTALL, P.A. (2001). Characterisation of immunoglobulin-G binding proteins in male Rhipicephalus appendiculatus ticks. Proceedings of the 10th International Congress of Acarology. CSIRO Publishing. pp.620-623.

NUTTALL, P.A., PAESEN, G.C., LAWRIE, C.H., HAJNICKA, N., FUCHSBERGER, N., AND WANG, H. (2001). Vector-host interaction in spirochete transmission. In: Spirochetes: Molecular and Cellular Biology, pp 53-60, M.H. Saier & J. Garcialara (Eds), Horizon Scientific Press, Wymondham

NUTTALL, P.A., PAESEN, G.C., LAWRIE, C.H., AND WANG, H. (2000). Vector-host interaction in disease transmission. Journal of Molecular Microbiology and Biotechnology 2: 381-386.

WONG, B.S., WANG, H., BROWN, D.R., AND JONES, I.M. (1999). Selective oxidation of methionine residues in prion proteins. Biochemical and Biophysics Research Communication 259:352-355.

WANG, H.*, AND NUTTALL, P.A. (1999). Immunoglobulin binding proteins in ticks: New target for vaccination development against the blood-feeding parasite. Cellular and Molecular Life Sciences 56: 286-295.

WANG, H., KAUFMAN, W.R., AND NUTTALL, P.A. (1999). Molecular individuality: polymorphism of salivary gland proteins in three species of ixodid tick. Experimental and Applied Acarology 23:969-975.

WANG, H., HENBEST, P.J, AND NUTTALL, P.A. (1999). Successful interrupted feeding of adult Rhipicephalus appendiculatus (Ixodidae) is accompanied by re-programming of salivary gland protein expression. Parasitology 119:143-149.

WANG, H., PAESEN, G.C, NUTTALL, P.A., AND BARBOUR, A.G. (1998). Male ticks aid female feeding. Nature 391:753-754.

WANG, H. AND NUTTALL, P.A. (1998). Fate of host immunoglobulin acquired in the tick blood meal.  The Second International Conference on Tick-Borne Pathogens at the Host-Vector Interface: A Global Perspective. Edited by Lewis Coons and Marjorie Rothschild. Vol (1): 264-268.

NUTTALL, P.A. and WANG, H. (1998). The potential role of tick immunoglobulin-binding protein in pathogen transmission. The Second International Conference on Tick-Borne Pathogens at the Host-Vector Interface: A Global Perspective. Edited by Lewis Coons and Marjorie Rothschild. Vol (1): 269-273.

WANG, H. (1997) Immunoglobulin binding proteins: a new strategy for an anti-tick vaccine development. The Proceedings of the International Forum on Tick and Tick-Borne Disease. A Supplement to Compendium on Continuing Education for the Practising Veterinarian. Vol 19(10):34-36.

WANG, H. AND NUTTALL, P.A.  (1995). Immunoglobulin G binding proteins in male Rhipicephalus appendiculatus tick. Parasite Immunology 17: 517-524.

WANG, H. AND NUTTALL, P.A. (1995).  Immunoglobulin-G binding proteins in ixodid ticks (Rhipicephalus appendiculatus, Amblyomma variegatum, Ixodes hexagonus). Parasitology 111: 161-165.

WANG, H. AND NUTTALL, P.A. (1994).  Excretion of host immunoglobulin in tick saliva and detection of IgG-binding protein in tick haemolymph and salivary gland.  Parasitology 109: 517-523.

WANG, H. AND NUTTALL, P.A. (1994).  Comparison of the proteins in salivary glands, saliva, and haemolymph of Rhipicephalus appendiculatus female ticks during feeding.  Parasitology 109: 525-530.

WANG, H. AND MENG, F.J. (1993).  Studies on zearalenone binding protein in the vernalized seeds of winter wheat (Triticum aestivum L.). Chinese Journal of Botany 5: 65-72.

MENG, F.J., HAN, Y.Z., QUE, Y.M., AND WANG, H. (1992). Zearalenone, a key substance controlling plant development. Progress in Plant Growth Regulation, in Current Plant Science and Biotechnology in Agriculture (ed. Karssen, C.M., Vanloon, L.C., and Vreugdenhil, D.): Vol:13, 291-297.

WANG, H., AND MENG, F.J. (1990). Studies on zearalenone combining substance in the vernalized seeds of Brassica chinensis L.  Chinese Journal of Botany 2: 159-164.

WANG, H., AND MENG, F.J. (1990). Formation of endogenous zearalenone and its inhibition by malathion in winter plants during vernalization. Acta Phytophysiol. Sin. 16: 197-200 (in Chinese with English summary).

 

Funding

2014-15   H. Wang (PI). Establishment of International Plant and Insect Pathogen Sequence Database (IPIPSD) Using Existing Deep Sequencing Data. NERC International Opportunities Fund 2013 (NE/L012863/1), £43K

2012-15    D. Bridget (PI), D. Cooper, C. Evans, L. May, M.J. Bowes, H. Jarvie, H. Wang (Co-I), S. Dadson, M. Dunbar, S.M. Smart. The Multi-Scale Response of Water quality, Biodiversity and C Sequestration to Coupled Macronutrient Cycling from Source to Sea. NERC Macronutrient Cycles Programme (NE/J011991/1), £75K to HW.

2012-13    H. Wang (PI) and P.A. Nuttall. IgA binding protein (Part-A). NERC Innovation Fund (MyIP 847), £ 19K

2012-15    J. Qin (Home PI) and H. Wang (Overseas PI). Collaboration research on human-related environmental microbiology using next generation sequencing technology. Ministry of Science and Technology of China (International Collaboration Research: 2011DFA33220), RMB 1.8M (approximatively £180K).

2011-12    H. Wang (Overseas PI) and M. Lu (Home PI). Small RNA investigation on the relationship of virus immunity and bamboo flowering. National Natural Science Foundation of China (Overseas Collaboration Research, 31028004), RMB200K (approximatively £20K).

2011         Hui Wang (PI) and Wei Huang. Alkane Biosensor. NERC Innovation Fund (815/A/Sept11/1), £ 10K

2010-12     H. Wang (PI) and R.D. Possee (Co-I). Development of a high throughput technology for detecting virus infection and immunity in the natural environment. NERC Technologies Proof of Concept Programme (NE/I000593/1), £99.6K

2007-10     H. Wang (PI), and A.F. Walls (Co-I). Plant virus infections as a determinant of pollen allergenicity. Joint Environment and Human Health Programme (NERC, Defra, EA, MOD, and MRC, NE/E008933/1), £ 150K (£ 74K to HW)

2006-12      P.A. Nuttall (PI), and H. Wang (Co-I). Ig-binding protein. NERC/Innovation B Fund, £ 96K

2004-07      T. Dalmay (PI, UEA) and H. Wang (Co-I, CEH-Oxford). Post-transcriptional gene silencing against viral infection in wild grasses. NERC/Nonthematic Programme (NER/A/S/00547, & NER/A/S/00548), £ 400K (£ 220K to HW)

2004-05      H. M. Sun (Named visiting Ph.D. student, Institute of Botany, Chinese Academy of Sciences), X. Jing (Supervisor, CAS), and H. Wang (Supervisor, CEH-OX). Travel and living subsistence for academic visit (for Molecular Biology) to the UK. State Scholarship Fund Award, China Scholarship Council (No. 2004491067), £ 9K

2004-05       Y. H. Li (Named visitor, Capital Normal University, Beijing, China) and H. Wang (Supervisor, CEH-Oxford). Travel and living subsistence for academic visit (for Plant Sciences) to the UK. Beijing Science & Technology Commission (H013610020112), £ 10K

2004            X. Q. Han (Named visitor, TsingHua University, Beijing, China) and H. Wang (Supervisor, CEH-Oxford). Travel and living subsistence for academic visit (for Protein Sciences) to the UK. Chinese Academy of Agricultural Sciences, £ 3K

2003-07        X. T. Ho (D.Phil. Student, University of Oxford) and H. Wang (Supervisor, CEH-Oxford). Grass-virus molecular interactions. Vietnamese Ministry of Education and Training (Decision No 322/QD-TTg), £ 65K

2003-06         M. J. Kearsey (PI, U.Birmingham), J. I. Cooper (Co-I, CEHOX), J. A. Walsh (Co-I, HRI), Z. Luo (Co-I, U.Birmingham), and H. Wang (Co-I, CEHOX). The genomics of plant-virus co-evolution in wild Brassica species. NERC/Environmental Genomics (NER/T/S/2002/00902, NER/T/S/2002/00991, NER/T/S/2002/00992), £ 530K (£163K to HW)

2001-05          H. Wang (named researcher and supervisor) and P. A. Nuttall (PI). Tick immunoglobulin binding proteins. NERC/Innovation A Fund, £ 58K

2000-03          H. Wang (named researcher and supervisor) and P. A. Nuttall (PI). Molecular individuality: does individual tick contribute its speciality to the group? NERC/ROPA, £ 120K

1997-2000       H. Wang (named researcher) and P. A. Nuttall (PI). Biodiversity at the parasite-host interface: functional role of immunoglobulin binding proteins. NERC/ROPA, £ 160K