Research Councils UK Academic Fellow

Senior Research Fellow, Linacre College

Research activity:

Within the broad research area of tissue engineering and stem cell technologies, my specific research interests lie in three interconnected areas, i.e. in vitro cancer model, biomaterials and bioreactor for tissue engineering and stem cell expansion.

Education:

2005    University College, Oxford University

           DPhil in Biochemical Engineering

           ORS Scholar & Applied Materials Research Scholar

           Thesis topic: Novel hollow fibre membrane bioreactors for growing three dimensional bone tissue

1998     School of Chemical Engineering, Dalian University of Technology, China

           BEng in Chemical Engineering

Work experience:

Mar 05-Sep 07                                    Post-doctoral Research Associate

                                                Department of Chemical Engineering, Imperial College London

Mar 04-Feb 05                                    Enterprise Fellow

                                                Begbroke Science Park, Oxford University

Publication:

JOURNAL PAPER

1.       Yue, X., Drakakis, E., Lim, M., Radomska, A., Ye, H., Mantalaris, A., Panoskaltsis, N., Cass, A. A real-time, multi-channel monitoring system for stem cell culture process. IEEE Trans Biomed Circuits Syst, 2, 66-77, 2008

2.       Radomska, A., Singhal, S., Ye, H., Lim, M., Mantalaris, A., Yue, X., Drakakis, E., Toumazou, C., Cass, A. Biocompatible ion selective electrode for monitoring metabolic activity during the growth and cultivation of human cells. Biosens Bioelectron, 24, 435-441, 2008

3.       Lim, M., Ye, H., Drakakis, E., Yue, X., Cass, A., Panoskaltsis, N., Mantalaris, A. Towards information-rich bioprocessing: generation of spatio-temporal profiles through the use of design of experiments to determine optimal number and location of sensors - an example in thermal profiles. Biochem Eng J, 40, 1-7, 2008

4.       Lim, M., Ye, H., Placzek, M., Mantalaris, A. Stem cell bioprocessing: Manufacturing cells for clinical applications. Bioworld Europe, S1, 10-13, 2007

5.       Lim, M., Ye, H., Panoskaltsis, N., Drakakis, E., Yue, X., Cass, A., Radomska, A., Mantalaris, A. Intelligent bioprocessing for haematopoietic cell cultures using monitoring and design of experiments. Biotech Adv, 25, 353-368, 2007

6.       Ye, H., Xia, Z., Ferguson D. J. P., Triffitt, J. T., Cui, Z. Studies on the use of hollow fibre membrane bioreactors for tissue generation by using rat bone marrow fibroblastic cells and a composite scaffold. J Mater Sci Mater Med, 18, 641-648, 2007

7.       Abdullah, N. S., Das, D. B., Ye, H., Cui, Z. 3D bone tissue growth in hollow fibre membrane bioreactor: implications of various process parameters on tissue nutrition. Inl J Artif Organs, 29, 841-51, 2006

8.       Ye, H., Das, D. B., Cui, Z., Triffitt, J. T. Modelling nutrient transport in hollow fibre membrane bioreactor for growing dense bone tissue. J Membrane Sci, 272, 169-178, 2006

9.       Xia, Z., Ye, H., Locklin, R. M., Ferguson, D. J., Cui, Z., Triffitt, J. T. Efficient characterization of human cell-bioceramic interactions in vitro and in vivo by using enhanced GFP-labelled mesenchymal stem cells. Biomaterials 26, 5790-5800, 2005

10.   Xia, Z., Ye, H., Choong, C., Ferguson, D. J., Platt, N., Cui, Z. Triffitt, J. T. Macrophagic response to human mesenchymal stem cell and poly(epsilon-caprolactone) implantation in nonobese diabetic/severe combined immunodeficient mice. J Biomed Mater Res 71A, 538-548, 2004.

BOOK CHAPTERS

1.       Lim, M., Ye, H., Panoskaltsis, N., Mantalaris, A. Optimal expansion and differentiation of cord blood stem cells using design of experiments: a case study on erythropoiesis. Handbook of Cardiac Stem Cell Therapy. Dimarakis, I., Menasche, P., Habib, N. A., Gordon, M. Y. Eds.. Imperial College Press, London. 2008

CONFERENCE PRESENTATIONS

1.       Lim, M., Ye, H., Panoskaltsis, N., Mantalaris, A. In-vitro erythropoiesis of cord blood haematopoietic stem cells using design of experiments. ISEH Annual Meeting, Hamburg, Germany, 2007

2.       Yue, X., Drakakis, E., Ye, H., Lim, M., Mantalaris, A., Panoskaltsis, N., Radomska, A.,  Toumazou, C., Cass, A. An on-line, multi-parametric, multi-channel physicochemical monitoring platform for stem cell culture bioprocessing. IEEE International Symposium on Circuits and Systems (ISCAS): 1215-1218, New Orleans, USA, 2007  (Live Demo Award) 

3.       Yue, X., Drakakis, E., Toumazou, C., Ye, H., Mantalaris, A., Radomska, A., Cass, A.  8×16 Channel physiological monitoring platform of stem cell culture systems. IEEE Biomedical Circuits and Systems Conference (BIOCAS), London, 2006

4.       Ye, H., Lim, M., Yue, X., Radomska, A., Cass, A., Drakakis, E., Panoskaltsis, N., Mantalaris, A., Toumazou, C. Ex vivo expansion and differentiation of haematopoietic stem cells (HSCs) using on-line monitoring and design of experiments (DOE): case study of erythropoiesis of cord blood stem cells. Oral presentation at AIChE Annual Conference, San Francisco, USA, 2006

5.       Lim, M., Ye, H., Panoskaltsis, N., Mantalaris, A. Full Process Characterization of Haematopoietic Stem Cell Cultures Using Design of Experiments to Study Individualistic and Interactive Effects of Culture Parameters. Oral presentation at AIChE Annual Conference, San Francisco, USA, 2006

6.       Das, D. B., Ye, H., Abdullah, N. S., Cui, Z. F. Modelling nutrient transport in hollow fibre membrane bioreactors for bone tissue growth. Oral presentation at 4th Annual Meeting of the European Tissue Engineering Society, Munich, Germany, 2005

7.       Ye, H., Das, D. B., Cui, Z. F. Modelling Hollow Fibre Membrane Bioreactor for Growing Bone Tissues: Effects of Process Parameters. Oral presentation at Engineeing with Membranes: Medical and Biological Applications, Camogli, Italy, 2005

8.       Ye, H., Xia, Z., Ferguson D. J. P., Triffitt, J. T., Cui, Z. Hollow-fibre membrane bioreactors for 3D tissue generation. Cytotherapy 6[3], 276, 2004. Oral presentation at Strategies in Tissue Engineering, Würzburg, Germany, 2004

9.       Xia, Z., Ye, H., Ferguson D. J. P., Cui, Z., Triffitt, J. T. Transfection efficiency and fate of eGFP-labelled human mesenchymal stem cells incorporating ceramics in NOD/SCID mice. Cytotherapy 6[3], 264, 2004. Oral presentation at Strategies in Tissue Engineering, Würzburg, Germany, 2004

10.   Xia, Z., Choong, C., Ye, H., Platt, N., Cui, Z., Triffitt, J. T. Macrophagic response to human osteogenic stem cells in SCID/NOD mice. Tissue Engineering 8[6], 1250. 2002. Poster presentation at the 5^th Annual Meeting of the Tissue Engineering Society International, Kobe, Japan, 2002

11.   Ye, H., Xia, Z., Ferguson D. J. P., Cui, Z., Triffitt, J. T. Evaluation of biocompatibility of scaffolds for orthopaedic tissue engineering using enhanced green fluorescent protein (EGFP)-labeled human bone marrow fibroblastic stem cells. Poster presentation at the Third Smith & Nephew Symposium-Translating Tissue Engineering into Products, Atlanta, USA, 2002

12.   Xia, Z., Ye, H., Ferguson D., Cui, Z., Triffitt, J. T. Interactions of calcium phosphate ceramics with green fluorescent protein (GFP)-labelled human bone marrow osteogenic stem cells. Oral presentation at the 3^rd Annual Symposium of the Tissue and Cell Engineering Society, Stoke-on-Trent, UK, 2001

PATENT

Cui, Z.F, Triffitt, J., Z, Xia., H, Ye.  "Method and structure for growing living organic tissue", GB/0121986.4,          Applicant: ISIS Innovation Ltd   (2001), PCT/GB2002/004126,  EU Patent Granted in  09 May 2007, Patent Number 05784379.9-1521-GB2005003614

Teaching:

Lectures:

• C5B Biosystem Modelling 
• C6/BME2 Tissue Engineering
• Centre for Doctoral Training in Healthcare Innovation

Lab organisation:

• Tissue Engineering Lab for MSc in Biomedical Engineering
• Biochemical Engineering Coursework Module
• Cell characterisation for Centre for Doctoral Training in Healthcare Innovation

Email: hua.ye@eng.ox.ac.uk

Tel: 0044 1865 617689

PhD Opportunities: