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Yee Kai Tee

Alumni of Wolfson College

Qualcom Scholarship Student

DPhil Research

Monitoring Stroke Using pH

Stroke is one of the leading causes of mortality worldwide. Each year billions of pounds are spent on the direct and indirect costs of stroke. On average, someone dies of a stroke every few minutes and the majority of those who avoid death suffer from some form of permanent disability.

My DPhil research is to study amide proton transfer (APT) or more widely known as chemical exchange saturation transfer (CEST) imaging – an MRI diagnostic technique which has been shown to correlate better than the current clinical practice (perfusion and diffusion mismatch) in identifying the tissue at risk after stroke.

This new MRI technique has obtained some novel breakthroughs in the animal model but several hardware and regulatory limitations have prevented it from becoming a routine clinical tool. The main aim of my work is to translate this promising MRI technique to aid decision making for acute stroke management.