CDT Postgraduate Studentship in Healthcare Innovation (RCUK Digital Economy Programme grant number EP/G036861/1)
Engineering Microbubbles for Quantitative Imaging
Ultrasound imaging is a powerful real time modality that currently accounts for over a quarter of all clinical imaging procedures in the UK. The relatively low cost of the equipment, portability and patient safety is unique to medical imaging modalities. Progressive research into Microbubble Contrast Agents, encapsulated gas bubbles between 1 to 10µm in diameter, has shown the potential to enable quantitative ultrasound measurements. Contrast Enhanced Quantitative Ultrasound (CEQUS) imaging has the potential for accurate detection of tumours and cardiovascular diseases. However a significant challenge is the prediction of interaction between microbubbles, their environment and an ultrasound field. The characterisation of a microbubble’s shell properties is therefore essential for developing a model that can predict their behaviour accurately. My current work presents a design and feasibility study into a novel characterization method, combining simultaneous acoustic and optical measurements from unconstrained single microbubbles.