CDT Postgraduate Studentship in Healthcare Innovation
(RCUK Digital Economy Programme grant number EP/G036861/1)
Delivering siRNA and mRNA to cells with shock waves
Many diseases result from the faulty production of proteins by cells. Short sequences of nucleic acid can be designed to specifically ‘knock-down’ this faulty production and reverse the disease. Unfortunately delivering nucleic acid into the cells so that it can contact its target is an inefficient process. Here we will investigate the use of shock waves (which are already employed for several other medical applications) as a mechanical force to temporarily open up cell membranes in order to enhance transfer of the nucleotide into diseased cells. If successful this technique would result in more effective therapies with lower side-effects.