CDT Postgraduate Studentship in Healthcare Innovation (RCUK Digital Economy Programme grant number EP/G036861/1)
Quantifying Impaired Metabolism Using Chemical Exchange Saturation MRI
In a condition like stroke it is important to be able to understand what is happening to cells that are being starved of nutrients because their blood supply has been reduced. This can be difficult to achieve in critically ill patients. However, Magnetic Resonance Imaging methods now permit such information to be acquired with a high level of detail and Oxford has a facility that permits such images to be obtained in stroke patients soon after hospital admission.
This project will exploit a relatively new MRI technique that can measure pH in the brain tissue of patients, which can be used as an indicator of cell health – potentially providing a prediction of which tissue can be rescued if treatment is applied swiftly. The project will improve the accuracy with which we can make these pH measurements making this technique more useful in clinical research and ultimately in clinical practice.